Autologous skin punch grafting in localized, fixed vitiligo

Authors

  • Tahir Jamil Ahmad
  • Tariq Rashid
  • Zahida Rani
  • Tahir Saeed Haroon

Keywords:

Autologous, punch graft, vitiligo

Abstract

Background A number of medical modalities including photo(chemo)therapy, topical and systemic steroids etc. are used in the treatment of vitiligo. Surgical treatment like punch grafting is recommended for localized, fixed disease.  Objectives To assess the clinical efficacy and safety of autologous skin punch grafting in patients with localized, fixed vitiligo. Patients and methods 40 adult cases (26 females and 14 males) having 207 localized vitiligo patches, unresponsive to medical measures for more than a year were included in the study. After investigations, they were subjected to test grafting and later to complete grafting of involved areas. Donor grafts were taken from normal areas. Results More than 85% patches showed good to excellent response after three months of grafting and PUVA therapy. No alarming side effects were recorded. Conclusion Autologous skin punch grafting is a safe, effective and promising mode of treatment in cases of localized fixed vitiligo. 

References

Shah SA, Aftab S, Goplani S. Prevalence of vitiligo in skin clinic. J Pak Assoc Dermatol 1991; 1: 14-9.

Najoo MD, Westerhof W, Bos JD, Bossuyt PMM. A systemic review of autologous transplantation methods in vitiligo. Arch Dermatol 1998; 134: 1543-9.

Papadopolus L, Bor R, Legg C, Howk JLM. Impact of life events on the onset of vitiligo in adults. Preliminary evidence for psychological dimension in aetiology. Clin Exp Dermatol 1998; 23: 243-8.

Halder RM, Young CM. New and emerging therapies for vitiligo. Dermatol Clin 2000; 18: 79-88.

Qureshi AA, Qureshi AS, Shah SA. Vitiligo. J Pak Assoc Dermatol 1992; 2: 1-16.

Boersma BR, Westerhof W, Bos JD. Repigmentation in vitiligo vulgaris by autologous minigrafting - results in nineteen patients. J Am Acad Dermatol 1995; 33: 990-5.

Grimes PE. Vitiligo: an overview of therapeutic approaches. Dermatol Clin 1993; 11: 325-38.

Njoo MD, Spuls PI, Boss JD, Bossuyt PMM. Non surgical repigmentation therapies in vitiligo: meta-analysis of the literature. Arch Dermatol 1998; 134: 1532-40.

Njoo MD, Bos JD, Westerhof W. Treatment of generalized vitiligo in children with narrow band (TL-01) UVB radiation therapy. J Am Acad Dermatol 2000; 42: 245-53.

Parsricha JS, Khaitan BK. Oral minipulse therapy with betamethasone in vitiligo patients having extensive or fast spreading disease. Int J Dermatol 1993; 32: 753-7.

Sahin S, Hindioglhu U, Karaduman A. PUVA treatment of vitiligo. A retrospective study of Turkish patients. Int J Dermatol 1999; 38: 542-5.

Camacho F, Mazuecos J. Treatment of vitiligo with oral and topical phenylalanine: six years of experience. Arch Dermatol 1999; 135: 1514-21.

Njoo MD, Westernhof W, Bos JD, Bossuyt PMM. The development of guidelines for the treatment of vitiligo. Arch Dermatol 1999; 135: 1514-21.

Savant SS. Autologous miniature punch grafting in stable vitiligo. Ind J Dermatol Venereol Leprol 1992; 58: 310-4.

Orentreich N, Selmanowitz VJ. Autograft repigmentation of leukoderma. Arch Dermatol 1972; 105: 734-6.

Falabella R. Repigmentation of segmental vitiligo by autologous minigrafting. J Am Acad Dermatol 1983; 9: 514-21.

Falabella R. Treatment of localized vitiligo by autologous minigrafting. Arch Dermatol 1988; 124: 1649-55.

Billingham RE, Silvers WK. Studies on the migratory behavior of melanocytes in guinea pig skin. Int J Exp Med 1970; 131: 101-117.

Drake LA, Dinehart SM, Farmer ER et al. Guidelines of care for vitiligo. J Am Acad Dermatol 1996; 35: 620-6.

Downloads

Published

2017-01-03

How to Cite

1.
Ahmad TJ, Rashid T, Rani Z, Haroon TS. Autologous skin punch grafting in localized, fixed vitiligo. J Pak Assoc Dermatol [Internet]. 2017Jan.3 [cited 2024Apr.17];13(3):114-6. Available from: http://jpad.com.pk/index.php/jpad/article/view/744

Issue

Section

Original Articles

Most read articles by the same author(s)

1 2 3 4 5 6 7 8 9 10 > >>