Comparative evaluation of hydroquinone, tretinoin and mometasone versus glycolic acid versus trichloroacetic acid peel in melasma

Authors

  • Seeba Hussain
  • Md Raihan
  • Abhijeet Kumar Jha
  • Satyaki Ganguly
  • Kranti Chandan Jaykar
  • Paritosh Kumar Banerjee

Keywords:

Melasma, hydroquinone, tretinoin, mometasone, glycolic acid, trichloroacetic acid

Abstract

Objective Comparative evaluation of 2% hydroquinone, 0.025% tretinoin and 1% mometasone versus glycolic acid and trichloroacetic acid peel alone in melasma.Methods Seventy five patients were included in the study. Total duration of study was one and a half years. Melasma area severity index (MASI) score of more than 10 were included in the study. The patients were divided into three groups. Group A consisted of 25 patients and were given 2% Hydroquinone, mometasone 1% and 0.025% tretinoin. Group B consisted of 25 patients and underwent glycolic acid peel. Group C consisted of 25 patients and underwent trichloroacetic acid peel. Results Group A had better response, followed by group B and group C, respectively. Conclusion Combination of hydroquinone, mometasone and tretinoin is a good option to treat melasma only when used judiciously along with sunscreen, whereas glycolic acid peels are a safer option with fewer side effects.

References

Pasricha JS, Khaitan BK, Dash S. Pigmentary disorders in India. Dermatol Clin. 2007;25:343-52.

Vázquez M, Maldonado H, Benmamán C, Sánchez JL. Melasma in men: A clinical and histological study. Int J Dermatol. 1988;27:25-7.

Pérez M, Sánchez JL, Aguiló F. Endocrinologic profile of patients with idiopathic melasma. J Invest Dermatol. 1983;81:543-5.

Garcia A, Fulton JE Jr. The combination of glycolic acid and hydroquinone or kojic acid for the treatment of melasma and related conditions. Dermatol Surg. 1996;22:443-7.

Lawrence N, Cox SE, Brody HJ. Treatment of melasma with Jessner's solution versus glycolic acid: a comparison of clinical efficacy and evaluation of the predictive ability of Wood's light examination. J Am Acad Dermatol. 1997;36:589-93.

Piamphongsant T. Treatment of melasma: a review with personal experience. Int J Dermatol. 1998;37:897-903.

Kligman AM, Willis I. A new formula for depigmenting human skin. Arch Dermatol. 1975;111:40-8.

Javaheri SM, Handa S, Kaur I, Kumar B. Safety and efficacy of glycolic acid facial peel in Indian women with melasma. Int J Dermatol. 2001;40:354-7.

Hurley ME, Guevara IL, Gonzales RM, Pandya AG. Efficacy of glycolic acid peels in the treatment of melasma. Arch Dermatol. 2002;138:1578-82.

Pathak MA, Fitzpatrick TB, Kraus EW. Usefulness of retinoic acid in the treatment of melasma. J Am Acad Dermatol. 1986;15:894-9.

Chun EY, Lee JB, Lee KH. Focal trichloroacetic acid peel method for benign pigmented lesions in dark-skinned patients. Dermatol Surg. 2004;30:512-6.

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Published

2016-11-18

How to Cite

1.
Hussain S, Raihan M, Jha AK, Ganguly S, Jaykar KC, Banerjee PK. Comparative evaluation of hydroquinone, tretinoin and mometasone versus glycolic acid versus trichloroacetic acid peel in melasma. J Pak Assoc Dermatol [Internet]. 2016Nov.18 [cited 2024Mar.28];26(1):31-4. Available from: http://jpad.com.pk/index.php/jpad/article/view/71

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