Superficial chemical peeling with glycolic acid in melasma

Safoora Aamir, Tariq Rashid, Haroon Nabi, Tahir Saeed Haroon

Abstract


Background Melasma is an acquired hyperpigmentation of exposed parts of face and neck,
for which various treatment options are available. Chemical peeling is an established
treatment modality for melasma.
Objective The aim of this study was to assess the safety and efficacy of glycolic acid peel in
our patients with melasma where the predominant Fitzpatrick skin type is IV and V.
Patients & methods A prospective therapeutic trial was carried out in the Department of
Dermatology, Mayo Hospital Lahore Pakistan from May 1999 to February 2000.Twenty
adult females (age range 18-38 years) with melasma (epidermal n=15, mixed n=3, dermal
n=2) were enrolled. Trial was conducted as a series of six fortnightly hospital-based peeling
sessions with increasing concentration of glycolic acid (20%-50%), and nightly application of
tretinoin, 5% glycolic acid and 2% hydroquinone. Patients were followed up for a period of
two months after completion of treatment.
Results The mean pre-peel and post-peel melasma area and severity index (MASI) scores
were 16.56 and 3.8 respectively, showing a significant reduction of about 75% (p< 0.05).
Among the two clinical patterns seen in our patients, malar distribution responded better as
compared to the centrofacial. Mild and reversible complications noted were erythema (90%),
peeling (70%), crusting (55%), post-inflammatory hyperpigmentation (20%) and moist
maceration (10%).
Conclusion Superficial chemical peeling with glycolic acid is safe and effective treatment
modality for melasma in our population.


Keywords


Chemical peeling, melasma, glycolic acid

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References


Sanchez NP, Pathak MA, Sato S,

Fitzpatrick TB et al. Melasma: A

clinical, light microscopic,

ultrastructural, and immunofluorescence

study. J Am Acad Dermatol 1981; 4:

-710.

Matarasso SL, Glogau RG. Chemical

face peels. Dermatol Clin 1991; 9: 131-

Brody HJ, Hailey CW. Medium depth

chemical peeling of the skin. A

variation of superficial chemosurgery. J

Dermatol Surg Oncol 1986, 12: 1268-

Moy LS, Moy RL, Murad H. Glycolic

acid peels for the treatment of wrinkles

and photoaging. J Dermatol Surg Oncol

; 19: 243-6.

Gilchrest BA, Fitzpatrick TB, Anderson

RR et al. Localization of melanin

pigmentation in the skin with Wood's

lamp. Br J Dermatol 1977; 96: 245-8.

Kimbrough-Green CK, Griffiths EM,

Finkel LJ et al. Topical retinoic acid

(tretinoin) for melasma in black

patients. Arch Dermatol 1994; 130:

-33.

Griffiths CE, Finkel LT, Ditre CM et al.

Topical tretinoin improves melasma: A

vehicle-controlled clinical trial. Br J

Dermatol 1993; 129: 415-21.

Pathak MA, Fitzpatrick TB, Kraus EW.

Usefulness of retinoic acid in the

treatment of melasma. J Am Acad

Dermatol 1986; 15: 894-9.

Perricone NV, DiNardo JC.

Photoprotective and anti-inflammatory

effects of topical glycolic acid.

Dermatol Surg 1996; 22: 435-7.


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