Palisaded encapsulated neuroma: A unique presentation
Keywords:
Palisaded, encapsulated, neuromaAbstract
Palisaded encapsulated neuroma(PEN) is a benign intraneural neuroma presenting as a solitary, sessile,immobile, asymptomatic, skin-coloured papule or nodule, commonly affecting the butterfly area of the face of a middle-aged person.It is not associated with neurofibromatosis or multiple endocrine neoplasia.We hereby report a unique case presenting with a firm,nodular growthover the posteromedial aspect of right kneewhich progressively increased in size over one year.On the basis of histopathologic findings,diagnosis of palisaded encapsulated neuroma was made.It is imperativeto diagnose it histopathologically, because it is more commonly misdiagnosed clinically with schwannoma and neurofibroma.References
Reed R, Fine R, Meltzer H. Palisaded encapsulated neuromas of the skin. Arch Dermatol. 1972;106:865-70.
Newman MD, Milgraum S. Palisaded Encapsulated Neuroma (PEN): An often misdiagnosed neural tumor.Dermatol Online J.2008;14 (7):12.
Golod O, Soriano T, Craft N. Palisaded encapsulated neuroma-A classic presentation of a commonly misdiagnosed neural tumor. J Drugs Dermatol. 2005;4:92-4.
Halder C, Sen S, Gangopadhyay A, Bala S. Zosteriform palisaded encapsulated neuroma: An unusual presentation. Indian J Dermatol. 2013;58:492.
Argenyi ZB. Immunohistochemical characterization of palisaded, encapsulated neuroma. J Cutan Pathol. 1990;17:329-35.
Dover J, From L, Lewis A. Palisaded encapsulated neuromas. A clinicopathologic study. Arch Dermatol. 1989;125:386-9.
Dubovy SR, Clark BJ. Palisaded encapsulated neuroma (solitary circumscribed neuroma of skin) of the eyelid: Report of two cases and review of the literature. Br J Ophthalmol. 2001;85:949-51.
Koutlas IG, Scheithauer BW. Palisaded encapsulated (“solitary circumscribedâ€) neuroma of the oral cavity: A review of 55 cases. Head Neck Pathol. 2010;4:15-22.