Epidermolytic hyperkeratosis a histological hallmark in the diagnosis of bullous ichthyosiform erythroderma

Authors

  • Asher Ahmed Mashhood
  • Nadia Iftikhar
  • Zafar Iqbal Sheikh

Keywords:

Bullous ichthyosiform erythroderma, epidermolytic hyperkeratosis

Abstract

Bullous ichthyosiform erythroderma is an uncommon form childhood keratinizing disorder. Early in life it is associated with generalized blistering and erythroderma. Later on it produces rippled type of hyperkeratosis. The diagnosis is confirmed by a very characteristic histopathology. It is described as “epidermolytic hyperkeratosis”. The purpose of this report is to highlight the features of epidermolytic hyperkeratosis and discuss the differential diagnosis of this histological entity. 

References

Shwayder T. All about ichthyosis. Pediatr Clin North 1991; 38: 835-57.

Frost P, Weinstein GD, Van Scott EJ. The ichthyosiform dermatoses II. Autoradiographic studies of epidermal proliferation. J Invest Dermatol 1996; 47: 561-7.

Fuchs E. Genetic Skin disorders of keratin. J Invest Dermatol 1992; 99: 671-4.

Comton JG, Digiovanna JJ, Santucci SK. Linkage of epidermolytic hyperkeratosis to the type II keratin gene cluster on chromosome 12q. Nat Genet 1992; 1: 301-5.

Rothnagel JA, Dominey AM, Dempsey MD. Mutations in the rod domains of keratins 1 and 10 in epidermolytic hyperkeratosis. Science 1992; 257: 1128-30.

DiCiovanna JJ, Bale SJ. Clinical heterogeneity in epidermolytic hyperkeratosis. Arch Dermatol 1994; 130: 1026-35.

Holbrook KA, Dale BA, Sybert VP. Epidermolytic hyperkeratosis: ultra structure and biochemistry of skin and amniotic fluid cells from two affected fetus and new born infants. J Invest Dermatol 1983; 80; 222-7.

Ackerman AB. Histopathological concepts of epidermolytic hyperkeratosis. Arch Dermatol 1970; 102: 253-59.

Blanchet-Bardon C, Nazarro V, Rognin C et al. Acitretin in the treatment of severe disorders of keratinization. J Am Acad Dermatol 1991; 24: 982-6.

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Published

2016-12-24

How to Cite

1.
Mashhood AA, Iftikhar N, Sheikh ZI. Epidermolytic hyperkeratosis a histological hallmark in the diagnosis of bullous ichthyosiform erythroderma. J Pak Assoc Dermatol [Internet]. 2016Dec.24 [cited 2025Feb.16];19(3):168-70. Available from: http://jpad.com.pk/index.php/jpad/article/view/535

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Section

Case Reports

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