Epidemiologic evaluation of patients with blistering lesions in Sari: A retrospective study

Masoud Gholpour, Ghasem Rahmatpour Rokni, Mohmmad Rahmani, Bahareh Gholpour, Ali Morad Heidari gorji



 Blistering diseases of skin are characterized by presence of lesions containing watery liquids. The aim of our study was to apply  the histopathological and demographical evaluation  of the patients whose medical records were in the archive of pathology unit of Buali hospital in Sari.

 Methods and Materials:

 This was a descriptive retrospective study included medical records of  87 patients with bullous lesions during years 2003-2013 which were archived in the pathology unit of the hospital, were reviewed and evaluated. Biopsies were taken by dermatologist after sterilizing of the bullous lesion with betadine and applying local anesthesia with lidocaine 1%. After appropriate tissue slicing, fixation and H&E staining, the samples were observed under microscope by two pathologists.Histopathological and demographic data (such as age, sex, area of involvement, diagnosis)  were recorded. The gathered information were analyzed by SPSS Ver. 16 in terms of central and peripheral statistic distribution.Results:

The population of our study was 87 patients and all of them had bullous lesions.the most common diagnoses was Pemphigus Vulgaris with 36 patients (41.4%), then Bullous Pemphigoid with 22 patients (25.3%), Dermatitis Herpetiformis with 8 patients (9.2%) , Pemphigus Foliaceus with 6 patients (6.9%), EpidermolysisBullosa with 4 patients (4.6%) Pemphigus Erythematosis with 3 patients (3.4%) and Subcorneal Pustular Dermatosis with 1 patient (1.1%) and 7 cases had uncertain diagnoses.Conclusion:

 Our study demonstrated that the frequency of diagnosis of skin bullous lesions in city of Sari is almost similar to other related studies and the most common diagnoses are pemphigus vulgaris, bullous pemphigoid, herpetiform dermatitis and pemphigus foliaceus. The ratio of female to male was 1.17:1.


Skin bullous disease, Pemphigus Vulgaris,BullousPemphigoid, Pemphigus foliaceus

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Bickle KM, Roark TR, Hsu S. Autoimmune bullous dermatoses: a review. American family physician 2002;65(9):1861-82.

Stanley JR. Pemphigus. In: Freedberg IM, Eisen AZ, Wolff K, et al, editors. Fitzpatrick's Dermatology in general medicine. 5th ed. New York: McGraw-Hill, Health Professions Division; 1999.p.654–66.

Chams‐Davatchi C, Valikhani M, Daneshpazhooh M, Esmaili N, Balighi K, Hallaji Z, et al. Pemphigus: analysis of 1209 cases. International journal of dermatology 2005;44(6):470-76.

Stanley JR. Bullous pemphigoid. In: Freedberg IM, Eisen AZ, Wolff K, et al, editors. Fitzpatrick's Dermatology in general medicine. 5th ed. New York: McGraw-Hill, Health Professions Division; 1999.p.666–79.

Nikolski P. Materiali K. uchenigu o pemphigus foliaceus. doctoral thesis] Kiev; 1896.

-Bastuji-Garin S, Souissi R, Blum L, Turki H, Nouira R, Jomaa B, et al. Comparative epidemiology of pemphigus in Tunisia and France: unusual incidence of pemphigus foliaceus in young Tunisian women. Journal of investigative dermatology 1995;104(2):302-5.

Fine JD. Inherited epidermolysisbullosa: past, present, and future. Annals of the New York Academy of Sciences 2010;1194(1):213-22.

Sawamura D, Nakano H, Matsuzaki Y. Overview of epidermolysisbullosa. The Journal of dermatology 2010;37(3):214-9.

Fine JD, Bauer EA, McGuire J, Moshell A, editors. EpidermolysisBullosa: Clinical, Epidemiologic, and Laboratory Advances and the Findings of the National EpidermolysisBullosa Registry. Baltimore, Md: Johns Hopkins University Press; 1999

Pérez-Pérez ME, Avalos-Díaz E, Herrera-Esparza R. Autoantibodies in senear-usher syndrome: cross-reactivity or multiple autoimmunity? Autoimmune diseases 2012;2012.

Kumar KA. Incidence of pemphigus in Thrissur district, south India. Indian Journal of Dermatology, Venereology, and Leprology 2008;74(4):349.

Sneddon I, Wilkinson D. Subcornealpustulardermatosis. British Journal of Dermatology 1956;68(12):385-94.

SNEDDON IB, WILKINSON DS. Subcornealpustulardermatosis. British Journal of Dermatology 1979;100(1):61-8.

Schmidt E, Zillikens D. Modern diagnosis of autoimmune blistering skin diseases. Autoimmunity reviews 2010;10(2):84-9.

Sagi L, Baum S, Agmon-Levin N, Sherer Y, Katz BSP, Barzilai O, et al. Autoimmune bullous diseases: the spectrum of infectious agent antibodies and review of the literature. Autoimmunity reviews 2011;10(9):527-35.

Sticherling M, Erfurt-Berge C. Autoimmune blistering diseases of the skin. Autoimmunity reviews 2012;11(3):226-30.

Arundhathi S, Ragunatha S, Mahadeva K. A Cross-sectional Study of Clinical, Histopathological and Direct Immunofluorescence Spectrum of Vesiculobullous Disorders. Journal of clinical and diagnostic research: JCDR 2013;7(12):2788.

Nanda A, Dvorak R, Al‐Saeed K, Al‐Sabah H, Alsaleh QA. Spectrum of autoimmune bullous diseases in Kuwait. International journal of dermatology 2004;43(12):876-81.

Jowkar F, Sadat Sadati M, Tavana S, Agah MA. Epidemiology of Autoimmune Bullous Diseases and Therapeutic Modalities During a 10 Year Period in Iran. ActaDermatovenerologicaCroatica2014;22(4):246-246.

Daneshpazhooh M, Chams‐Davatchi C, Payandemehr P, Nassiri S, Valikhani M, Safai‐Naraghi Z. Spectrum of autoimmune bullous diseases in Iran: a 10‐year review. International journal of dermatology 2012;51(1):35-41.


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