Toxic Epidermal Necrolysis in Children Caused by Bulbus Fritillariae Cir-rhosae: Identification of Causative Drug Based on Alden Score
Keywords:
Bulbus Fritillariae cirrhosae, Pediatric, Stevens-Johnson syndrome, Toxic Epidermal NecrolysisAbstract
Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe, potentially fatal illnesses marked by widespread necrosis and separation of the epidermis and mucosal epithelium. A 10-year-old girl presented with blisters and whole-body rashes worsening since two days before admission, which developed after taking herbal medicine containing Bulbus Fritillariae cirrhosae (BFC) two days prior to the symptoms. The patient was diagnosed with TEN affecting 32.5% of body surface area and hospitalized for further treatment. Infection and drugs hypersensitivity are among the etiologies of SJS/TEN in children. The patient took herbal medicine containing BFC, which contains acetic acid, a substance reported to cause severe cutaneous adverse reactions. Since reports on SJS/TEN in children caused by herbal medicine remains scarce, vigilance towards the use of herbal medicine and further studies are needed.References
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