Platelet rich plasma in androgenetic alopecia: A critical analysis of current treatment modalities
Keywords:
Hair loss, Platelet rich plasma, Hair regenerationAbstract
We aimed to review the clinical research using PRP for the treatment of Androgenic alopecia. Furthermore, our other objective was to compare the PRP therapy with the traditional finasteride treatment to assess the better treatment in terms of efficacy. This systematic review was conducted by following the protocol defined by Khan et al.8 containing 5 step procedure to access high-quality relevant literature. Best Evidence Topic (BET) reports protocol was used for accessing the protocol, patient characteristics, intervention or defining question and relevant outcomes. All articles from Google scholar, PubMed, Conference Proceedings, Medline, and Cochrane Central Register for Controlled Trials were used in the first screening for gathering relevant information. Two independent authors were assigned to evaluate the study design. Only 5 studies of platelet-rich plasma and 5 studies of finasteride treatment were included. All the evidence was fulfilling the level 2 CEMB criteria. A total of 3538 patients were suffering from baldness. None of the study achieved 10 points. Only two platelet rich plasma studies while single study of finasteride treatment, were given 9 score. Results concluded that PRP is far way better than finasteride in terms of high hair growth in less duration, with minimum to no side effects.References
Semalty M, Semalty A, Joshi G. Hair growth and rejuvenation: An overview. J Dermatolog Treat. 2011;22(3):123-32.
Rushton D, Norris M, Dover R. Causes of hair loss and the developments in hair rejuvenation. Int J Cosmet Sci. 2002;24(1):17-23.
Alkhalifah A, Alsantali A, Wang E, McElwee K. Alopecia areata update: part I. Clinical picture, histopathology, and pathogenesis. J Am Acad Dermatol. 2010;62(2):177-88.
Rogers N, Avram M. Medical treatments for male and female pattern hair loss. J Am Acad Dermatol. 2008;59(4):547-66.
Finner A. Nutrition and hair: deficiencies and supplements. Dermatol Clin. 2013;31(1):167-72.
McElwee K, Shapiro J. Promising therapies for treating and/or preventing androgenic alopecia. Ski Ther Lett. 2012;17(6):1-4.
Andia I, Sánchez M, Maffulli N. Joint pathology and platelet-rich plasma therapies. Expert Opin Biol Ther. 2012;12(1):7-22.
Khan K, Kunz R, Kleijnen J, Antes G. Five steps to conducting a systematic review. JR Soc Med. 2003;96(3):118-21.
Mackway-Jones K, Carley S, Morton R. The best evidence topic report: a modified CAT for summarising the available evidence in emergency medicine. J Accid Emerg Med. 1998;15(4):222.
Glasziou P, Irwig L, Bain C, Colditz G. Systematic reviews in health care: a practical guide [Internet]. New York: Cambridge University Press; 2001 [cited 2016 Aug 26]. Available from: https://books.google.co.in/books?hl=en&lr=&id=dWn8PZNBZpwC&oi=fnd&pg=PP1&dq=Systematic+reviews+in+health+care+a+practical+guide+/+Paul+Glasziou+...+%5Bet+al.%5D.&ots=mhV7JASm5p&sig=SyfuAQW4k2FvH2BPtGCmcoDUxcQ
Littell J, Corcoran J, Pillai V. Systematic Reviews and Meta-Analysis. Oxford University Press, USA; 2008. p202.
Alves R, Grimalt R. Randomized Placebo-Controlled, Double-Blind, Half-Head Study to Assess the Efficacy of Platelet-Rich Plasma on the Treatment of Androgenetic Alopecia. Dermatol Surg. 2016;42:491-7.
Cervelli V, Garcovich S, Bielli A, Cervelli G, Curcio BC, Scioli MG, et al. The effect of autologous activated platelet rich plasma (AA-PRP) injection on pattern hair loss: Clinical and histomorphometric evaluation. Biomed Res Int. 2014;2014:760709.
Gentile P, Garcovich S, Bielli A, Scioli MG, Orlandi A, Cervelli V. The effect of platelet-rich plasma in hair regrowth: a randomized placebo-controlled trial. Stem Cells Transl Med. 2012;4(11):1317-23.
Borhan R, Gasnier C, Reygagne P. Autologous Platelet Rich Plasma as a Treatment of Male Androgenetic Alopecia: Study of 14 Cases. J Clin Exp Dermatol Res. 2015;6(4):2-7.
Gkini MA, Kouskoukis AE, Tripsianis G, Rigopoulos D, Kouskoukis K. Study of platelet-rich plasma injections in the treatment of androgenetic alopecia through an one-year period. J Cutan Aesthet Surg. 2014;7(4):213-9.
Oliveira-Soares R, E Silva JM, Correia MP, André MC. Finasteride 5 mg/day Treatment of Patterned Hair Loss in Normo-androgenetic Postmenopausal Women. Int J Trichology. 2013;5(1):22-5.
Price VH, Menefee E, Sanchez M, Kaufman KD. Changes in hair weight in men with androgenetic alopecia after treatment with finasteride (1 mg daily): Three- and 4-year results. J Am Acad Dermatol. 2006;55(1):71-4.
Sato A, Takeda A. Evaluation of efficacy and safety of finasteride 1 mg in 3177 Japanese men with androgenetic alopecia. J Dermatol. 2012;39(1):27-32.
Hajheydari Z, Akbari J, Saeedi M, Shokoohi L. Comparing the therapeutic effects of finasteride gel and tablet in treatment of the androgenetic alopecia. Indian J Dermatol Venereol Leprol. 2009;75(1):47-51.
Rossi A, Cantisani C, Scarnò M, Trucchia A, Fortuna MC, Calvieri S. Finasteride, 1 mg daily administration on male androgenetic alopecia in different age groups: 10-year follow-up. Dermatol Ther. 2011;24(4):455-61.
Reese RJ, Edina DO. Autologous platelet rich plasma (PRP): what do we know ? Important concepts relevant to hair restoration surgery. Hair Transpl Forum Int. 2010;Feb:14-7.
Gluud LL. Bias in clinical intervention research. Am J Epidemiol. 2006;163(6):493-501.
Yeon J, Jung J, Choi J, Kim B. 5 mg/day finasteride treatment for normoandrogenic Asian women with female pattern hair loss. J Eur Acad Dermatology Venereol. 2011;25(2):211-4.
