Comparison of Therapeutic Effects of 4% and 10% Purple Passion Fruit (Passiflora Edulis Sims Var. Edulis) Seeds Extract Cream with 4% Hydroquinone Cream on Epidermal Type Melasma
Keywords:
Hydroquinone, Medicinal Plant, Purple passion fruit, Epidermal type melasmaAbstract
Background: Purple passion fruit seed extract (PPFSE) is rich in antioxidant and photoprotective and therefore has potential as alternative treatment for melasma Objective: This study aim to evaluate therapeutic effects of 4% and 10% PPFSE cream to 4% hydroquinone (HQ) cream for epidermal type melasma. Methods: A randomized double-blind clinical trial was conducted. The study participants were divided into three groups, PPFSE cream 4%, 10% group and HQ cream 4% group. Severity of melasma was assessed with modified melasma area severity index (mMASI), melanin index (MI) with Mexameter® and Mark-Vu® skin analysis and quality of life index for melasma with melasQol at baseline, week 4, 8, and 12 for each arm Results: A total of 38 participants were included. There was a significant reduction in mMASI, MI, and melasQol scores before and after 12 weeks of treatment across all groups (p=0.000). The difference between mMASI and melanin index before and after 12 weeks of treatment was lower in the PPFSE 4% than the HQ 4% (p<0.05) Conclusion: PPFSE cream 10% can be a viable option for treatment of epidermal type melasmaReferences
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