Combination of light-emitting diode with minoxidil 2%, topical corticosteroid and oral immunomodulator induced hair regrowth in a pediatric alopecia areata
Keywords:
Alopecia areata, diode, immunomodulator, pediatricAbstract
Alopecia areata (AA) is a form of non-scarring hair loss caused by an autoimmune disease. Symptoms range from a total or severe to an only mild patchy loss of hair. Spontaneous remission may occur. Even though AA is the third most frequent reason for pediatric dermatology consultations, treating alopecia areata in children is still difficult. A 4-year-old, healthy girl, presented with non-scarring multiple patchy alopecias on the scalp, and the hair pull test was positive. Trichoscopy demonstrated exclamation marks, black dots, short vellus hairs, and telangiectasia. Routine laboratory tests were unremarkable. The patient was clinically diagnosed with alopecia areata. Dermoscopy may confirm the diagnosis. Therapies are designed to alleviate symptoms and signs. More pediatric data are needed to evaluate therapies’ safeness and recurrence rates in such treatment approaches. Topical treatment using high potency topical corticosteroid and minoxidil 2% combined with light-emitting-diode (LED) and oral immunomodulator (inosine pranobex) showed good response and well tolerated in pediatric alopecia areata.References
References
WaÅ›kielâ€Burnat A, KoÅ‚odziejak M, Sikora M, Stochmal A, Rakowska A, Olszewska M, et al. Therapeutic management in paediatric alopecia areata: A systematic review. J Eur Acad Dermatol Venereol. 2021;35(6):1299-308.
Bains P, Kaur S. The role of dermoscopy in severity assessment of alopecia areata: A tertiary care center study. J Clin Aesthet Dermatol. 2020;13(4):45-50.
WaÅ›kielâ€Burnat A, Rakowska A, Sikora M, Olszewska M, Rudnicka L. Trichoscopy of alopecia areata in children. A retrospective comparative analysis of 50 children and 50 adults. Pediatr Dermatol. 2019;36(5):640-5.
Lusiana, Legiawati L, Siphra V, Gaol EL, Surachmiati L, Sitohang IBS. Outcomes of oral immunotherapy for the treatment of alopecia areata totalis: A case report. In: Yunir E, editor. Medical Case Reports. Jakarta: Nova Science Publishers Inc; 2020. p. 253-6.
Conic RZ, Tamashunas NL, Damiani G, Fabbrocini G, Cantelli M, Bergfeld WF. Comorbidities in pediatric alopecia areata. J Eur Acad Dermatol Venereol. 2020;34(12):2898-901.
Fernando T, Goldman RD. Corticosteroids for alopecia areata in children. Can Fam Physician. 2020;66(7):499-501.
Kawen AA. Association between cytomegalovirus infection and alopecia areata in Thi Qar Province Iraq. J Thi-Qar Univ. 2017;12(3):268-78.
Stoehr JR, Choi JN, Colavincenzo M, Vanderweil S. Off-label use of topical minoxidil in alopecia: A review. Am J Clin Dermatol. 2019;20(2):237-50.
Legiawati L, Anissa L. Relapse in alopecia totalis after successful treatment with intralesional corticosteroid and oral immunomodulator. J Ski Stem Cell. 2020;7(1):1-5.
Hamblin MR. Photobiomodulation for the management of alopecia: Mechanisms of action, patient selection and perspectives. Clin Cosmet Investig Dermatol. 2019;12:669-78.