Quality of life index evaluation in pemphigus vulgaris patients of Pakistan

Authors

  • Nadia Ali Azfar Fatima Jinnah Medical University/ Sir Ganga Ram Hospital, Lahore, Pakistan
  • Saima Ilyas
  • Maryum Qayyum
  • Zain Ali Raza
  • Muhammad Nadeem
  • Tariq Rashid

Keywords:

Key words, Pemphigus vulgaris, Immunobullous, Quality of Life Index

Abstract

Background Pemphigus vulgaris is an immunobullous disorder characterized clinically by recurrent painful ulcerations in the mucus membranes and erosive blisters all over the body.  Objective The aim of this study was to evaluate quality-of-life and mental health status in Pakistani patients suffering fom pemphigus vulgaris.  Methods A total of 40 patients with pemphigus were recruited from outpatient and indoor of Dermatology Unit-1, Jinnah hospital Lahore and Sir Ganga Ram hospital Lahore, from November, 2018 to June, 2019.  They were assessed clinically, and then interviewed using urdu version of Dermatology Life Quality Index (DLQI) questionnaire.  Results Out of the 40 patients, there were 17 male and 23 female patients. No statistical correlation was found between demographic variables (age, sex, education level, rural/urban) and DLQI scores. However, there was positive correlation between marital status and DLQI score(P=0.012) and negative correlation with chronicity of disease(P=0.018). The average DLQI score was 14±7. Symptoms and embarrassment caused by disease were the most effected DLQI variables while sex life, sports and work were least effected.  Conclusion DLQI is important in deciding treatment regimen especially in young, unmarried and those with recent symptoms. It can alert the physician regarding depression and anxiety in a patient. Quality of life can thus be greatly improved.  

Author Biography

Nadia Ali Azfar, Fatima Jinnah Medical University/ Sir Ganga Ram Hospital, Lahore, Pakistan

Associate Professor Dermatology

References

Wilson C, Wojnarowska F, Mehra NK, et al. Pemphigus in Oxford, UK and New Delhi: a comparative study of disease characteristics and HLA antigens. Dermatol 1994;189(1):108-110.

Mitev A, Rencz F, Tamasi B, et al. Subjective well-being in patients with pemphigus: a path analysis. Eur J Health Econ 2019;20(1):101-107.

Kouris A, Platsidaki E, Christodoulou C, et al. Quality of life, depression, anxiety and loneliness in patients with bullous pemphigoid. A case control study. An Bras Dermatol 2016;91(5):601-603.

Saddok RT, Saddock VA. Comprehensive textbook of psychiatry, 8th ed. New York: LWW 2004: 2031-2040.

Sung JY, Roh MR, Kim SC. Quality of life assessment in Korean patients with Pemphigus. Ann Dermatol 2015;27(5):492-498.

Wang EQ, Radjenovic M, Castrillon MA, et al. The effect of autoimmune blistering diseases on work productivity. J Eur Dermatol Venereol 2018;32(11):1959-1966.

Penha MA, Farat JG, Miot HA, et al. Quality of life index in autoimmune bullous dermatosis patients. An Bras Dermatol 2015;90(2):190-194.

Layegh P, Nahidi Y, Malekzadeh I, et al. Quality of life evaluation in patients with pemphigus vulgaris. Iran J Dermatol 2013;16:100-104.

Mayrshofer F, Herti M, Sinkgraven R, et al. Significant decrease in quality of life in patients with pemphigus vulgaris. Results from the German Bullous Skin Disease( BSD)Study Group. J Dtsch Dermatol Ges 2005;3:431-435.

Tabolli S, Maozzetta A, Antinone V, et al. The health impact of pemphigus vulgaris and pemphigus foliaceous assessed using the medical outcome Study 36-item short form health survey questionnaire. Br J Dermatol 2008;158:1029-1034.

Paradisi A, Sampogna F, Di Pietro C, et al. Quality of life assessment in patients with pemphigus using a minimum set of evaluation tool. J Am Acad Dermatol 2009;60:261-269.

Sebaratnam DF, Frew JW, Davatchi F, et al. Quality of life measurement in blistering diseases. Dermatol Clin 2012;30(2):301-307.

Morsya H, Abdel-Motaleba A, Solimanb A. Quality-of-life assessment in pemphigus vulgaris in Upper Egypt using the Dermatology Life Quality Index and SF-36 questionnaires. Egypt J Dermatol Venerol 2016; 36(1):1-3.

Ghodsi SZ, Chams‐davatchi C, Daneshpazhooh M et al. Quality of life and psychological status of patients with pemphigus vulgaris using Dermatology Life Quality Index and General Health Questionnaires. J Dermatol 2012;39:141-144.

Noor SM, Khurshid K, Mahmood T, et al. Quality of life in vitiligo patients. J Pak Assoc Dermatol 2004;14:55-58.

Chowdary NK, Shenoi SD, Nayak SUK, et al. Quality of life in acne patients: A clinical and dermatology life quality index (DLQI) based cross-sectional study. J Pak Assoc Dermatol 2018;28(4):415-419.

Rahman S, Aman S, Nisaruddin, et al. Quality of life assessment in patients of psoriasis. J Pak Assoc Dermatol 2018;28(2):186-192.

Layegh P, Nahidi Y, Malekzadeh I, et al. Quality of life evaluation in patients with pemphigus vulgaris. Iran J Dermatol 2004;16(65):100-104.

Downloads

Published

2021-03-04

Issue

Section

Original Articles