Frequency of oral involvement in patients with pemphigus vulgaris presenting in a tertiary care hospital Quetta

Dr. Saifullah, Sara Inayat, Anila Panezai, Mehvish Afridi, Dr. Habib Ullah, Sehrish Ghani

Abstract


Objective To determine frequency of oral involvement in patients with pemphigus vulgaris presenting in a tertiary care hospital Quetta.

 

Study Design Cross Sectional.

 

Setting and study duration This study was conducted in Dermatology department, Bolan Medical College/ Sandeman (P) Hospital Quetta. Approval was taken from the institutional ethical review board. The duration of study was six months from 21st September 2017 to 21st march 2018.

 

Material and methods A total of 89 patients with clinical diagnosis of pemphigus vulgaris were included in this study. Complete history and examination was taken for blister of skin and mucosal involvement. Biopsy of the blister lesion was sent to institutional laboratory to aid the diagnosis.

Data was analyzed on SPSS version 22. Mean and standard deviation was calculated for age of patients. Male and female ratio was calculated. Frequency and percentage was calculated for oral involvement in patients with Pemphigus Vulgaris. Data was stratified in different age group, gender and duration of symptoms to control effect modifier. Post stratification chi-square test was applied by taking P ≤ 0.05 as level of significance.

 

Results A total of 89 patients with clinical diagnosis of pemphigus vulgaris were included in this study. The average age of the patients was 49.85±6.28 years. There were 59(66.29%) male and 30(33.71%) female. Frequency of oral involvement in patients with pemphigus vulgaris was 86.52% (77/89).

 

Conclusion  Our results showed that Pemphigus is a potentially life threatening disease that causes blisters and erosions of the skin and mucous membranes. Frequency of oral involvement in patients with pemphigus vulgaris was 86.52%.  For prevention of worst complication early detection and treatment will help. Clinicians should make use of such combination therapy to achieve remission of the disease and to provide comfort to the patient.

 


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References


Uddin JM, Islam AM, Ali ME, Wahab MA, Khondker L, khan Md S I. Safety of parenteral dexamethasone vs. oral prednisolone in the treatment of pemphigus vulgaris. J Pak Assoc Dermatol. 2013;23(2):163-7.

Hasan S, IK Nabeel, AS Osama, B Vasundhara, S Himangi et al. Pemphigus vulgaris: An Insight on conventional and emerging treatment modalities. Int Res J Pharm.2013;4(3): 8-12.

Noorbala MT, Kafaie P, Poursina N, Ghavami M, Sadoughi S. Pemphigus in central part of Iran. J Pak Assoc Dermatol. 2012;22(3):197-9.

Hertl M, Jedlickova H, Karpati S, Marinovic B, Uzun S, et al. Pemphigus S2 Guideline for diagnosis and treatment--guided by the European Dermatology Forum (EDF) in cooperation with the European Academy of Dermatology and Venereology (EADV). J Eur Acad Dermatol Venereol. 2015; 29(3): 405-14.

Khan S W, Iftikhar N, Ahmed T A, Bashir M . HLA-DR Alleles in Pakistani patients of pemphigus vulgaris. J Coll Physicians Surg Pak. 2015;25(4):233-6.

Karagöz G, Bektaş-Kayhan K, Ünür M. Evaluation of pemphigus cases involving oral mucosa. Oral Health Dent Manag 2014; 13(3):605-9.

Stanley JR. Pemphigus. In Irwin Freedberg, ArhturEisen, Klaus Wolff editors. Fitzpatricks Dermatology in General Medicine. 5th edition New York. McGraw Hill. 60: 654-661.

Martinez AB, Corcuora MM, Gomez GE. Oral manifestations of pemphigus vulgaris. J Clin ExpDermatol Res. 2004; 1: 1-5.

Yazdanfar A. Epidemiology of pemphigus in Hamedan (West of Iran). A 10 year retrospective study .Int J of Pharma Biomed Res 2010; 1(4): 157-60.

Ali A, Aleraza Y. Pemphigus vulgaris in Iran epidemiology and profile. Skinmed 2006;5:69-71.

Anand AJ, Vaibhav T. Oral involvement in Pemphigus Vulgaris: An Epidemiological Profile. NJIRM. 2015; 6(5):50-53.

Jari Z, Meibodi NT, Nahidi Y. Epidemiology of Pemphigus in North East Iran. Indian J Dermatol 2007; 52:188-91.

Davatchi C, Valikhani C, Esmail M. Pemphigus. Analysis of 1209 cases. Int J Dermatol. 2005;44:470-76.

Karagoz G, Bektas K, Umar M. Evaluation of Pemphigus cases involving oral mucosa. Oral Health Dent Manag. 2014:13:3605-608.


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