Importance of dermoscopy in assisting the non-invasive diagnosis of Darier’s disease
Keywords:Darier’s disease, dermoscopy, hyperkeratosis, pseudocomedones, acantholysis
AbstractWe herein present a case of patient affected with Darier’s disease along with dermoscopic findings to raise awareness of importance of dermoscopy in non-invasive diagnosis of this disease. It allows specialists to differentiate the condition from other disorders with similar clinical and histopathological pictures, such as Grover’s disease, Hailey-Hailey disease and seborrheic dermatitis.
Leong IUS, Stuckey A, Ahanian T, Cederlöf M, Wikstrom JD. Novel mutations in Darier disease and association to self-reported disease severity. PLoS One. 2017;12(10):e0186356-e.
Sakuntabhai A, Ruiz-Perez V, Carter S, Jacobsen N, Burge S, Monk S, et al. Mutations in ATP2A2, encoding a Ca2+ pump, cause Darier disease. Nat Genet. 1999;21(3):271-7.
Burge SM, Wilkinson JD. Darier-White disease: a review of the clinical features in 163 patients. J Am Acad Dermatol. 1992;27(1):40-50.
Takagi A, Kamijo M, Ikeda S. Darier disease. The Journal of Dermatology. 2016;43(3):275-9.
Halteh P, Jorizzo JL, Lipner SR. Darier disease: candy-cane nails and hyperkeratotic papules. Postgraduate Medical Journal. 2016;92(1089):425-6.
V S, S S, B K YD, N R, T PK, R P, et al. Spectrum of features in Darier's disease: A case report with emphasis on differential diagnosis. J Oral Biol Craniofac Res. 2019;9(2):215-20.
Cederlof M, Bergen SE, Langstrom N, Larsson H, Boman M, Craddock N, et al. The association between Darier disease, bipolar disorder, and schizophrenia revisited: a population-based family study. Bipolar Disord. 2015;17(3):340-4.
Cederlof M, Karlsson R, Larsson H, Almqvist C, Magnusson PK, Nordlind K, et al. Intellectual disability and cognitive ability in Darier disease: Swedish nation-wide study. Br J Dermatol. 2015;173(1):155-8.
Gordon-Smith K, Jones LA, Burge SM, Munro CS, Tavadia S, Craddock N. The neuropsychiatric phenotype in Darier disease. British Journal of Dermatology. 2010;163(3):515-22.
Jones I, Jacobsen N, Green EK, Elvidge GP, Owen MJ, Craddock N. Evidence for familial cosegregation of major affective disorder and genetic markers flanking the gene for Darier's disease. Mol Psychiatry. 2002;7(4):424-7.
Ruiz-Perez VL, Carter SA, Healy E, Todd C, Rees JL, Steijlen PM, et al. ATP2A2 mutations in Darier's disease: variant cutaneous phenotypes are associated with missense mutations, but neuropsychiatric features are independent of mutation class. Hum Mol Genet. 1999;8(9):1621-30.
Errichetti E, Stinco G. Dermoscopy in General Dermatology: A Practical Overview. Dermatol Ther (Heidelb). 2016;6(4):471-507.
Oliveira A, Coelho de Sousa V, Pimenta R, Leal-Filipe P. Reflectance confocal microscopy in Darier disease: A case series with dermoscopic and histologic correlation. Skin Research and Technology. 2019;25(3):404-6.
Vázquez-López F, Lopez-Escobar M, Maldonado-Seral C, Perez-Oliva N, Marghoob AA. The handheld dermoscope improves the recognition of giant pseudocomedones in Darier's disease. Journal of the American Academy of Dermatology. 2004;50(3):454-5.
Errichetti E, Stinco G, Lacarrubba F, Micali G. Dermoscopy of Darier's disease. J Eur Acad Dermatol Venereol. 2016;30(8):1392-4.
Errichetti E, Maione V, Pegolo E, Stinco G. Dermoscopy: a useful auxiliary tool in the diagnosis of type 1 segmental Darier's disease. Dermatol Pract Concept. 2016;6(2):53-5.
Suryawanshi H, Dhobley A, Sharma A, Kumar P. Darier disease: A rare genodermatosis. J Oral Maxillofac Pathol. 2017;21(2):321-.
Chauhan P, Meena D, Hazarika N. Dermoscopy of Hailey Hailey Disease. Indian dermatology online journal. 2018;9(2):139-40.