Comparison of efficacy of intralesional 5-Flourouracil plus triamcinolone acetonide verses intralesional triamcinolone acetonide alone in the treatment of keloids

Authors

  • Nadia Ali Faisalabad Medical University/ DHQ Hospital, Faisalabad
  • Muhammad Arif Faisalabad Medical University/ DHQ Hospital, Faisalabad
  • Muhammad Shahid Faisalabad Medical University/ DHQ Hospital, Faisalabad
  • Kehkshan Tahir Ameer-ud-Din Medical College/ PGMI/ Lahore General Hospital, Lahore
  • Kalsoom Jawaid Nishtar Medical University/ Nishtar Hospital, Multan
  • Abid Hussain Faisalabad Medical University/ DHQ Hospital, Faisalabad

Keywords:

Keloid, 5-Flurouracil, triamcinolone acetonide

Abstract

  Background Keloid is a benign well demarcated area of dense, fibrous tissue overgrowth that extends beyond the original defect. It is a result of an overgrowth of granulation tissue at the site of a healed skin injury. A variety of treatment regimens have been used for the management of keloids but none proved satisfactory. Methods  A total of 150 patients (75 in each group), fulfilling inclusion and exclusion criteria, were included in the study after taking informed consent. Local anesthesia was given in the form of injection lignocaine sublesionally in both groups. In group A, injection 5-flurouracil 10mg/ml (0.2ml) plus triamcinolone acetonide 10mg/ml (0.25ml) was given intralesionally, 2mm apart. In group B, injections triamcinolone acetonide 10mg/ml (0.25ml) alone was given intralesionally, 2mm apart. These injections were repeated after 3 weeks in each group for a duration of 3 months. Photographs were taken at base line and the end of 14th week. Efficacy was measured in terms of >75% reduction in size of keloids (measured by a dialed caliper) from baseline till the end of 14 weeks. Results  Efficacy was achieved in 55% (n=43) of patients in group A and was achieved in 36% (n=27) of patients in group B. The difference in efficacy of both groups was statistically significant with p value of 0.00. Conclusion We concluded that the efficacy of intralesional 5-flurouracil plus triamcinolone acetonide is significantly higher than intralesional triamcinolone acetonide alone for the treatment of keloids.  

Author Biographies

Nadia Ali, Faisalabad Medical University/ DHQ Hospital, Faisalabad

Women Medical OfficerDermatology Department

Muhammad Arif, Faisalabad Medical University/ DHQ Hospital, Faisalabad

Associate ProfessorDermatology Department

Muhammad Shahid, Faisalabad Medical University/ DHQ Hospital, Faisalabad

Assistant ProfessorDermatology Department

Kehkshan Tahir, Ameer-ud-Din Medical College/ PGMI/ Lahore General Hospital, Lahore

Associate ProfessorDermatology Department

Kalsoom Jawaid, Nishtar Medical University/ Nishtar Hospital, Multan

Assistant ProfessorDermatology Department

Abid Hussain, Faisalabad Medical University/ DHQ Hospital, Faisalabad

Medical OfficerDermatology Department

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Published

2021-03-04

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