Update of skin immunosenescence in geriatric population
Keywords:
Immunosenescence, innate immune system, adaptive immune systemAbstract
Increased life expectancy must be in line with good health and independence at the end of life. Elderly is a state when numerous factors change, including molecular, cellular, physiological, immunological, and psychosocial factors, directly causing functional impairment, inability to adapt and accumulation of various organ failures. As age advances, the immune system undergoes characteristic changes, usually resulting in decreased immune competence, termed immunosenescence. The alterations that happen in immunosenescence, including the abnormal elevation, decrease, and dysregulations of innate and adaptive immune responses, lead to more severe consequences of bacterial and viral infections, also autoimmune diseases and cancer in elderlyReferences
Ventura MT, Casciaro M, Gangemi S, Buquicchio R. Immunosenescence in aging: Between immune cells depletion and cytokines up-regulation. Clin Mol Allergy. 2017;15:1-8.
Sunderkötter C, Kalden H, Luger TA. Aging and the skin immune system. Arch Dermatol. 1997;133:1256-62.
Fuentes E, Fuentes M, Alarcön M, Palomo I. Immune system dysfuction in the elderly. An Acad Bras Cience. 2017;89:285-99.
Torres SM, Berwick M. Melanoma and skin aging. In: Farage MA, Miller KW, Maibach HI. Textbook of aging skin. Springer. 2001. 582-3.
Panda A, Arjona A, Sapey E, Bai F, Fikrig E, Montgomery RR, et al. Human innate immunosenescence: Causes and consequences for immunity in old age. Trends Immunol. 2009;30:325-33.
Corsini E, Racchi M, Lucchi L, Donetti E, Bedoni M, Viviani B, et al. Skin immunosenescence: Decreased receptor for activated C kinase-1 expression correlates with defective tumour necrosis factor-α production in epidermal cells. Br J Dermatol. 2009;160:16-25.
Ginaldi L, Loreto MF, Corsi MP, Modesti M, Martinis MD. Immunosenescence and infectious diseases. Microbes Infect. 2001; 3(8):51-7.
Castle SC. Clinical relevance of age-related immune dysfunction. Clin Infect Dis. 2001;31:578-85.
Hakim FT, Flomert FA, Boyiadzis M, Gress RE. Aging, immunity, and cancer. Curr Opin Immunol. 2004;16:151-6.
Hasler P, Zouali M. Immune receptor signaling, aging, and autoimmunity. Cell Immunol. 2005;233:102-8.
