Cutaneous manifestations of systemic sclerosis

Veeresh Dyavannanavar, Shashikant Malkud


Background  Systemic sclerosis (SSc) is a multi-system disorder that affects skin and other organ systems. It is a disease of unknown etiology with an interplay between vascular and collagen maturation factors. It has varied mucocutaneous manifestations and immunological features that are helpful in initial diagnosis and subsequent classification of the disease.


Objective To study the mucocutaneous manifestations and immunological profile in patients of SSc.


Methods  Thirty one patients of SSc attending to dermatology department over a period of 2 years were included in the study. Detailed history regarding age, sex, occupation, duration of complaints and evolution of the lesions were noted. Routine laboratory investigations, biochemical and immunological profile were done.


Results The common presenting features were Raynaud’s phenomenon in 30 (96.7%), pigmentary changes in 29 (93.5%), sclerodactyly in 28 (90.3%), microstomia 25 (80.6%), fingertip ulceration and scarring in 18 (58.1%) and flexion contractures of the fingers in 10 (32.2%) patients. Mucosal and nail changes were observed in 8 (25.8%) and 10 (32.2%) patients respectively.  Diffuse cutaneous SSc was noted in 17 (54.8%) and limited cutaneous SSc in 14 (45.2%) patients. Twenty (64.5%) patients tested positive for ANA.


Conclusion  The study showed the spectrum of mucocutaneous and immunological profile of SSc patients in south Indian population.



diffuse, limited, sclerosis

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Sharma VK, Trilokraj T, Khaitan BK, Krishna SM. Profile of systemic sclerosis in a tertiary care center in North India. Indian J Dermatol Venereol Leprol 2006; 72:416-20.

Medsger TA, Masi AT. Epidemiology of Systemic sclerosis. Ann Intern Med.1971; 74: 712-14.

Ghosh SK, Bandyopadhyay D, Saha I, Barua JK. Mucocutaneous and demographic features of systemic sclerosis: A profile of 46 patients from Eastern India. Indian J Dermatol. 2012;57:201-5.

Mitchel H, Bolster MB, Leroy EC et al. Scleroderma and related conditions. Med clinic North Am 1997;81:129-51.

Tuffanelli DL, Winkelmann RK. Systemic scleroderma: A clinical study of 727 cases. Arch Dermatol 1961;84:359-71.

Preliminary criteria for the classification of systemic sclerosis (scleroderma). Subcommittee for scleroderma criteria of the American Rheumatism Association Diagnostic and Therapeutic Criteria Committee. Arthritis Rheum 1980;23:581-90.

Bhagavandas K. Premalatha S, Yesudian P et al. PSS – An analytical study. J Assoc Physicians India 1980; 75: 65-7.

Malaviya AN, Adhar GC, Pasricha JS. Connective tissue diseases in India III. Clinical and immunological profile of progressive systemic sclerosis. J Assoc Physicians India 1979;27:395-400.

Gupta HL, Balakrishna M. Clinical profile of Systemic sclerosis in Women. J Indian Med Assoc 1987;85:38-40.

Flower C, Nwankwo C. Systemic sclerosis in an Afro-Caribbean population: A review of demographic and clinical features. West Indian Med J 2008;57:118.

Krishnamurthy V, Porkodi R, Ramakrishnan S, Rajendran CP, Madhavan R, Achuthan K, et al. Progressive systemic sclerosis in south India. J Assoc Physicians India 1991; 39:254-7.

Kumar A, Malaviya AN, Tiwari S et al. Clinical and laboratory profile of Systemic sclerosis in Northern India. J Assoc Physicians India 1990;38(10):765-8.

Al-Adhadh RN, Al-Sayed TA. Clinical features of Systemic sclerosis. Saudi Med J 2001;22: 333-6.

Tuffanelli DL, Winkelmann RK, Minn R. Systemic scleroderma a clinical study of 727 cases. Arch Dermatol 1961;84: 359-71.

Teh CL, Kuan YC, Wong JS. Systemic sclerosis in Sarawak: A profile of patients treated in the Sarawak General Hospital. Rheumatol Int 2009;29:1243-5.

Tan EM. Rodan GP, Gareun J et al. Diversity of Anti Nuclear Antibodies in Progressive Systemic sclerosis. Arthritis Rheum 1980;23: 617-25.

Sato S, Fujimoto M, Ihn H et al. Antibodies to centromere and centriole in scleroderma spectrum of disorders. Dermatologica 1994; 189: 23–6.


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