Safety and efficacy of hydroxychloroquine in patients of symptomatic oral lichen planus

Megha Sondhi, Karaninder Singh Mehta, Vikram Mahajan, Pushpinder Singh Chauhan, Ashish Minhas, Niharika Dhattarwal, Ashwani Rana

Abstract


Background A wide variety of therapies have been used to treat symptomatic oral lichen planus (OLP). Role of anti-malarial agents in oral lichen planus is not fully studied.

 

Aim To evaluate safety and efficacy of hydroxychloroquine in the treatment of symptomatic OLP.

 

Methods Thirty seven patients with symptomatic OLP were included in the study. Patients were started on tablet hydroxychloroquine 200 mg twice daily and continued for a period of 6 months. Clinical evaluation was performed at the beginning of the treatment and then every 2 months during 6-month period of active treatment and thereafter again after 6 months of follow-up. Pain and clinical evaluation were done using visual analogue scale (VAS) and Thongprasom scale.

 

Results Thirty-seven patients were included; however, 7 patients were lost to follow-up, and excluded from final analysis. At the time of completion of therapy, 80% of the patients had no lesions. There was no recurrence until 6 months after completion of therapy. Gastritis was the most common adverse event. There were no other serious adverse events.

 

Conclusion Hydroxychloroquine is the effective and safe treatment for symptomatic OLP.

 


Keywords


Oral lichen planus, hydroxychloroquine, anti-malarials

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References


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