Mean platelet volume in patients with psoriasis vulgaris and its relationship with disease severity

Pooner Faiz Aman, Dr. Farid-ur-Rehman, Asma Javed Kiyani, Sobia Awan, Ayesha Kiran, Bilqees Fatima


Objective To determine Mean Platelet volume (MPV) in patients with psoriasis vulgaris (PV) and to compare its relationship with disease severity.


Patients and Methods This cross-sectional study was conducted in Dermatology department of Fauji Foundation Hospital, Rawalpindi.100 patients were recruited through the outpatient clinic. Diagnosis was made on relevant history, and clinical examination, Psoriasis Area Severity Index (PASI) and Body Mass Index (BMI) was recorded. Laboratory parameters included CBC (hemoglobin, White blood cell, platelet count, MPV) was measured using an auto-analyzer (SysmexX2000Germany). Alanine aminotransferase (ALT), Blood urea nitrogen (BUN), Creatine, Plasma sugar levels, Uric acid, Serum cholesterol, Hepatitis B and C screening and a baseline ECG was performed.


Results  MPV was significantly higher in patients with psoriasis vulgaris (p<0.05), In addition there was a positive correlation between (PASI) and MPV. Mean MPV was 8.63 0.67fL (with minimum MPV was 7.8 fL while maximum was 9.9fL) (p<0.05).


Conclusion  MPV is elevated among patients of psoriasis vulgaris and is significantly increased in patients with PASI ≥ 10.



Psoriasis; Mean Platelet volume; Psoriasis Area Severity Index; Atherosclerosis

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Parisi R, Symmons DP, Griffiths CE, et al. Global epidemiology of psoriasis: a systematic review of incidence and prevalence. J Invest Dermatol. 2013; 133:377–85.

Di Meglio P, Villanova F, Nestle FO. Psoriasis. Cold Spring Harb Perspect Med 2014; 4:8.

Raychaudhuri SK, Maverakis E, Raychaudhuri SP. Diagnosis and classification of psoriasis. Autoimmun Rev. 2014; 13:490–5.

Tamagawa-Mineoka R. Important roles of platelets as immune cells in the skin. J Dermatol Sci 2015; 77:93-101.

Fong W. Lam, K. Vinod Vijayan, Rolando E. Rumbaut. Platelets and their interactions with other immune cells. Compr Physiol 2015; 5: 1265–80.

Leader A, Pereg D, Lishner M. Are platelet volume indices of clinical use? a multidisciplinary review. Ann Med 2012; 44:805-16.

Markovic D, Carevic V, Bonacin D. Correlation between mean platelet volume and total risk of cardiovascular disease. J Am Coll Cardiol 2013; 40:418–23.

Kılıç S, Reşorlu H, Işik S, Oymak S, Akbal A, Hız MM et al. Association between mean platelet volume and disease severity in patients with psoriasis and psoriatic arthritis. Postepy Dermatol Alergol. 2017 ;34(2):126-30.

Kim DS, Lee J, Kim SH, Kim SM, Lee MG. Mean platelet volume is elevated in patients with psoriasis vulgaris. Yonsei Med J. 2015;56(3):712-8.

Tollefson MM, Crowson CS, McEvoy MT. Incidence of psoriasis in children: a population-based study. J Am Acad Dermatol 2010; 62:979–87.

Parisi R, Symmons DP, Griffiths CE. Identification and Management of Psoriasis and Associated Comorbidity (IMPACT) project team. Global epidemiology of psoriasis: a systematic review of incidence and prevalence. J Invest Dermatol 2013; 133:377–85.

Zaheer Ahmad, Shahid Javaid Akhtar, Muhammad Arif Maan, Uzma Khalid, Abid Hussain. Comparison of mean platelet volume in patients with psoriasis and healthy individuals. J Pak Asso Dermatol 2014; 24:1-3.

Canpolat F, Akpinar H, Eskioğlu F. Mean platelet volume in psoriasis and psoriatic arthritis. Clin Rheumatol. 2010;29(3):325-8.

Enas A. M. Mahrous.The relationship between platelet volume and risk of atherosclerosis in patients with psoriasis. Egypt J Dermatol Venereol. 2018; 38:29–36.

Saleh HM, Attia EA, Onsy AM, Saad AA, Abd Ellah MM. Platelet activation: a link between psoriasis per se and subclinical atherosclerosis--a case. Br J Dermatol. 2013; 169(1):68-75.


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