Mean platelet volume in patients with psoriasis vulgaris and its relationship with disease severity

Pooner Faiz Aman, Dr. Farid-ur-Rehman, Asma Javed Kiyani, Sobia Awan, Ayesha Kiran, Bilqees Fatima

Abstract


Objective To determine Mean Platelet volume (MPV) in patients with psoriasis vulgaris (PV) and to compare its relationship with disease severity.

 

Patients and Methods This cross-sectional study was conducted in Dermatology department of Fauji Foundation Hospital, Rawalpindi.100 patients were recruited through the outpatient clinic. Diagnosis was made on relevant history, and clinical examination, Psoriasis Area Severity Index (PASI) and Body Mass Index (BMI) was recorded. Laboratory parameters included CBC (hemoglobin, White blood cell, platelet count, MPV) was measured using an auto-analyzer (SysmexX2000Germany). Alanine aminotransferase (ALT), Blood urea nitrogen (BUN), Creatine, Plasma sugar levels, Uric acid, Serum cholesterol, Hepatitis B and C screening and a baseline ECG was performed.

 

Results  MPV was significantly higher in patients with psoriasis vulgaris (p<0.05), In addition there was a positive correlation between (PASI) and MPV. Mean MPV was 8.63 0.67fL (with minimum MPV was 7.8 fL while maximum was 9.9fL) (p<0.05).

 

Conclusion  MPV is elevated among patients of psoriasis vulgaris and is significantly increased in patients with PASI ≥ 10.

 


Keywords


Psoriasis; Mean Platelet volume; Psoriasis Area Severity Index; Atherosclerosis

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