Retrospective analysis of severe cutaneous adverse drug reactions over a period of 6 years

Youssef Moutaouakkil, Rachid el Jaoudi, Samira Serragui, Yahia Cherrah, Jamal Lamsaouri, Samir Siah, Yassir Bousliman


Background severe cutaneous adverse reactions are a group of potentially lethal adverse drug reactions. Prompt diagnosis and management may reduce the morbidity and mortality. Early identification of the offending drug is necessary for early withdrawal and to prevent the recurrences of such a devastating illness.


Aims To study the demography, offending agents, clinical features and treatment, complications, morbidity and mortality of SJS/TEN in our hospital.


Materials and Methods In this retrospective study, we reviewed the medical records of SJS, TEN, SJS/TEN overlap of inpatients over a period of 6 years.


Results Among the 16 patients included, 7 (43,75%) were male with a mean age of 46.2 ± 15 years. Antimicrobials were the commonest group of drugs causing SCAR in 8/16 patients (50%). The most common morbidity noted in our study was due to sepsis leading to acute renal failure. The SCORTEN score for 5 TEN cases ranged from 0 to 5. Two of the SJS/TEN cases died giving a mortality rate of 12.50% (2/16).


Conclusion Antibiotics are the common offending agents of SJS/TEN in our study.



Severe cutaneous adverse reactions; Stevens-Johnson syndrome; toxic epidermal necrolysis; retrospective analysis

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