Co-supplementation of oral antioxidant to PUVASol therapy has no effect on oxidative stress index in patients of unstable vitiligo: A hospital based pilot study

Gaurav Bhardwaj, Jaspreet Kaur

Abstract


Background In recent years, interest has grown in studying the role of oxidative stress in vitiligo, so measurement of the combined activities of all antioxidants or the Total antioxidant status (TAS) is often used to estimate the overall antioxidant status. Likewise, Total oxidant status (TOS) is measured to determine a patient’s overall oxidation state. Furthermore, the oxidative stress index (OSI), which is calculated as the ratio of TOS to TAS, may be a more accurate index of oxidative stress in the body. This study was done to measure the effect of oral antioxidant supplementation therapy for 1 month on the oxidative stress index in patients of vitiligo.

 

Methods In this pilot study 40 consecutive patients presenting in departmental vitiligo clinic were enrolled and randomly allocated into 2 groups of 20 patients each were prescribed oral prednisolone at a dosage of 1mg/kg for 2 consecutive days/week along with oral 8-methoxypsoralen on 3 alternate days in a week at a dose of 0.6mg/kg body weight. Patients in group B received the following antioxidants orally along with treatment of group A. End point of the study was 1 month of continuous therapy in the respective groups. OSI was calculated before initiating treatment by serum collection.

 

Results The mean OSI decreased significantly in both the study groups individually (P = 0.037 & 0.040 for Group A and B respectively). However inter-group comparison between the 2 study groups showed no statistically significant difference (P = 0.052).

 

Conclusion Addition of antioxidants to PUVASol in treatment of unstable vitiligo has no effect on oxidative stress index.

 


Keywords


Vitiligo, PUVASol, total oxidant status, total antioxidant status, oxidative stress index

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References


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