A retrospective observational study on clinical and histopathological correlational analysis of malignant melanoma

Qazi Syed Irfanullah Shah, Shaista Rasheed, Paride Abliz, Fan Jun Wei, xuefeng wan


Background Malignant melanoma derives from the neuroectodermal mucosa. Melanoma accounts for 1-3 percent of malignancies in children and adults. The incidence and clinical properties of the disease are multifactorial and have biological and environmental variables. Tumor thickness was correlated to age, blood supply, site and nerve supply separately.


Objective This study was made to determine the clinical and histopathological correlation of malignant melanoma.


Material and Methods A retrospective observational study was conducted at a tertiary care hospital, Urumqi in China to study the clinical and histopathological correlation of malignant melanoma. A detailed history and thorough physical examination of patients, lab tests including primary or secondary tumor biopsies, complete blood count and PET scans help in diagnosis. Clinical staging was done on the basis of regional lymph node involvement and distant metastasis.


Results The highest no. of patients (28.20%) was recorded for 60-69 years age group followed by (25.64%) in 70-79 years age group. The largest no. (30.76%) of cases comprised of acral lentiginous melanoma as well as nodular melanoma followed by lentigo maligna melanoma (20.51%) and superficial spreading melanoma (17.95%). The highest no. of patients (35.90%) had tumor thickness of 1-2 mm followed by (20.51%) cases had 2-4 mm, (17.95%) cases had <1 mm. However, not a single patient had tumor thickness of >4 mm in our study.


Conclusion This study investigated histopathological and clinical results. The main result we found was that the trunk was involved to major extent than the periphery. Frequently involved subtypes were nodular melanoma and acral melanoma. Female are more commonly affected in this study then male 2:1.



Malignant Melanoma, Skin Tumor, Tumor Staging, Clark Level, Breslow Thickness

Full Text:



Norton SA. Betel: consumption and consequences. J Am Acad Dermatol 1998; 38(1): 8188.

Tilakaratne WM, Klinikowski MF, Saku T, Peters TJ, Warnakulasuriya S. Oral submucous fibrosis: a review on etiology and pathogenesis. Oral Oncol 2006; 42(6): 561-568.

Prasad ML, Busam KJ, Patel SG, Hoshaw Woodard S, Shah JP and Huvos AG: Clinicopathologic differences in malignant melanoma arising in oral squamous and sinonasal respiratory mucosa of the upper aerodigestive tract. Arch Pathol Lab Med 127: 997 1002, 2003.

Aldrink JH, Selim MA, Diesen DL, Johnson J, Pruitt SK, Tyler DS, et al. Pediatric melanoma: a single-institution experience of 150 patients. J Pediatr Surg 2009; 44: 1514– 1521.

Moore-Olufemi S, Herzog C, Warneke C, Gershenwald JE, Mansfield P, Ross M et al. Outcomes in pediatric melanoma: comparing prepubertal to adolescent pediatric patients. Ann Surg 2011; 253: 1211–1215.

Hamre MR, Chuba P, Bakhshi S, Thomas R, Severson RK. Cutaneous melanoma in childhood and adolescence. Pediatr Hematol Oncol 2002; 19: 309–317.

Strouse JJ, Fears TR, Tucker MA, Wayne AS. Pediatric melanoma: risk factor and survival analysis of the surveillance, epidemiology and end results database. J Clin Oncol 2005; 23: 4735–4741.

Bauer J, Buttner P, Murali R, et al. BRAF mutations in cutaneous melanoma are independently associated with age, anatomic site of the primary tumor and the degree of solar elastosis at the primary tumor site, Pigment Cell Melanoma Res 2011; 24:345-351.

Sekulic A, Haluska P Jr, Miller AJ, et al. Malign melanoma in the 21st century: the emerging molecular landscape, Mayo Clin Proc. 2008; 83(7): 825-46.

Reintgen DS, McCarty KM Jr, Cox E, et al. Malignant melanoma in black American and white American populations: a comparative review. JAMA 1982; 248:1856-9.

Kukita A, Ishihara K. Clinical features and distribution of malignant melanoma and pigmented nevi on the soles of the feet in Japan. J Invest Dermatol 1989; 92: 210S-213S.

Collins RJ. Melanoma in the Chinese of Hong Kong: emphasis on volar and subungual sites. Cancer 1984; 54:1482-8.

Choi SJ, Bae YC, Moon JS, et al. An analysis of the clinical and histopathological pattern of malignant melanoma. J Korean Soc Plast Reconstr Surg 2007; 34: 557-61.

Ackerman AB. What naevus are dysplastic, a syndrome and the commonest precursor of malignant melanoma? A riddle and an answer. Histopathology. 1988; 13: 241-56. PMID:3056824

Togawa Y, Nakamura Y, Kamada N, Kambe N, Takahashi Y, Matsue H. Melanoma in association with an acquired melanocytic nevus in Japan: a review of cases in the literature. Int J Dermatol 2010; 49: 1362. PMID: 21155082

Sheen YS, Liao YH, Lin MH, Chiu HC, Jee SH, Liau JY, et al. Insulin-like growth factor II mRNA-binding protein 3 expression correlates with poor prognosis in acrallentiginous melanoma. PLoS One. 2016; 11: e0147431.

Al-Jamal MS, Griffith JL, Lim HW. Photoprotection in ethnic skin. Dermatologica Sinica 2014; 32:217-24.

MacKie R, Hunter JA, Aitchison TC, Hole D, McLaren K, Rankin R, et al. Cutaneous malignant melanoma, Scotland, 1979–89. The Scottish Melanoma Group. Lancet 1992; 339: 971–975.

Breslow A. Thickness, cross-sectional areas and depth of invasion in the prognosis of cutaneous melanoma. Ann Surg 1970; 172: 902–908.

Balch CM, Soong SJ, Gershenwald JE, Thompson JF, Reintgen DS, Cascinelli N, et al. Prognostic factors analysis of 17,600 melanoma patients: validation of the American Joint Committee on Cancer melanoma staging system. J Clin Oncol 2001; 19: 3622–3634.


  • There are currently no refbacks.

ISSN: 1560-9014