General paresis of the insane - A rare case report

Seethalakshmi Ganga vellaisamy, Subramania Adityan Murugan


General Paresis of the Insane (GPI) is a meningoencephalitis as a result of direct invasion of Treponema pallidum into the cerebrum, typically develops between 15 and 20 years after initial infection. Mr. X is a 50 year old painter referred to Venereology Department from Neurology Department with 3 years history of gradually progressive behavioural disturbances along with disturbances in speech & difficulty in writing. Blood VDRL & CSF VDRL was found to be reactive. A diagnosis of GPI was made and the patient was treated appropriately. He showed remarkable improvement following treatment.




General Paresis of Insane; Crystalline Penicillin; Lumbar puncture;

Full Text:




Lishman WA.: Organic Psychiatry: The psychological consequences of cerebral disorder. Blackwell Scientific Publicatioa London 1987 PP:277-288.

Dewhurst K. The neurosyphilitic psychoses today: a survey of 91 cases. Br J Psychiatry 1969; 115: 31-38.

Dawson- Butterworth K, et al. Review of hospitalized cases of general paresis of the insane. Br J Vener Dis 1970;46: 295-302.

Ambrose King & Claude Nicol. Neurosyphilis. In: Venereal diseases. 3rd Edition.Newyork;Bailliere Tindall Publications ;1975 P.85

Hart G. Syphilis tests in diagnostic and therapeutic decision making. Ann Intern Med 1986;104: 368-376

Ganti SR, et al. Computed tomography of Cerebral syphilis. J Comput Assist Tomogr 1981; 5: 345.

Centers for Disease Control and Prevention. 1998 Sexually Transmitted Diseases Treatment Guidelines. MMWR 1998; 47: 28-41.

Marra CM, et al.: A Pilot study evaluating ceftriaxone and penicillin G as treatment agents for neurosyphilis in human immunodeficiency virus- infected individuals. Clin Infect Dis 2000, 30:540- 544.

Hook EW 3rd : Azithromycin compared with penicillin G benzathine for treatment of incubating syphilis. Ann Intern Med 1999,131: 434-437.


  • There are currently no refbacks.

ISSN: 1560-9014