Methicillin resistant stahphylococcus aureus (MRSA) septicemia in pemphigus foliaceus - A coalition partners in resistant cases

Anuradha Jindal, Dr. Raghavendra Rao


Infection contributes to considerable morbidity and mortality in patients with autoimmune bullous disorders (AIBDs) such as pemphigus. Increased susceptibility to infection in this population may occur via 3 primary mechanisms- defective barrier function as a result of blistering and subsequent erosions, down regulation of immunity due to medications used in the treatment of AIBDs and finally, immune dysregulation associated with autoimmunity.1 In pemphigus, sepsis is the most common cause of death, with staphylococcus aureus being the most frequently implicated organism.2 We hereby report two cases of methicillin resistant staphylococcus aureus (MRSA) septicemia in pemphigus foliaceus (PF) patients rendering them resistant to conventional immunosuppressive therapies.



MRSA, pemphigus foliaceus

Full Text:



Lehman JS, Murrell DF, Camilleri MJ, Kalaaji AN. Infection and Infection Prevention in Patients Treated with Immunosuppressive Medications for Autoimmune Bullous Disorders. Dermatol Clin. 2011; 29: 5 91-8.

A.R. Ahmed, R. Moy. Death in pemphigus. J Am Acad Dermatol. 1982; 7: 221–228.

Hammers CM, Stanley JR. Desmoglein-1, differentiation, and disease. J Clin Invest. 2013; 123: 1419-22.

Whittock NV, Bower C. Targetting of desmoglein 1 in inherited and acquired skin diseases. Clin Exp Dermatol.2003;28:410-5

Amagai M. Desmoglein as a target in autoimmunity and infection. J Am Acad Dermatol.2003; 48: 244-52.

Hanakawa Y, Stanley JR. Mechanisms of blister formation by staphylococcal toxins. J Biochem 2004; 136: 747-50.


  • There are currently no refbacks.

ISSN: 1560-9014