Efficacy of benzoyl peroxide and clindamycin combination therapy with benzoyl peroxide alone in the treatment of acne vulgaris

Isabela Kabir, Muhammad Munir Rashid, Lubna Khondker

Abstract


Objective To assess the efficacy of benzoyl peroxide and clindamycin combination therapy with benzoyl peroxide alone in the treatment of acne vulgaris.

 

Methods A clinical trial was carried out in the Department of Dermatology and Venereology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka. The study duration was from July 2013 to December 2013. Total sixty patients of clinically diagnosed mild to moderate acne was enrolled and thirty of group A patients were treated by benzoyl peroxide alone and thirty of group B patients were treated by benzoyl peroxide and clindamycin combination therapy.

 

Results At baseline mean number of comedones in group A and group B was 12.77±4.01 and 11.80±3.93, respectively (p=0.350) and at final follow-up 4.17±4.02 and 3.47±4.00 (p>0.05). At baseline mean number of papules in group A and group B was 17.30±10.29 and 18.57±13.88, respectively (p=0.690) and at final follow-up 7.63±8.08 and 7.73±9.98 (p>0.05). At baseline mean number of pustules in group A and group B was 0.50±1.33 and 0.53±1.28, respectively (p=0.922) and at final follow-up 0.07±0.37 and 0.00 (p>0.05). At baseline mean of total acne score was 30.57±13.62 and 30.90±17.17 in group A and B and at final follow-up it was 11.87±12.04 and 11.20±13.85, respectively in group A and B (p>0.05). Percent reduction of acne severity from baseline to final follow-up was 69.20±23.41 in group A and 74.77±23.30 in group B (p=0.360). At final follow-up 56.7% of group A and 63.3% of group B achieved excellent response and 13.3% of group A and 16.7% of group B achieved good response.

 

Conclusion It can be concluded that the drug, benzoyl peroxide when used individually, was found to be effective in the treatment of acne, but the combination of the two clindamycin and benzoyl peroxide was found to be superior in efficacy.

 


Keywords


Efficacy, benzoyl peroxide, clindamycin, acne vulgaris

Full Text:

PDF

References


Gollnick H, Cunliffe W, Berson D, Dreno B, Finlay A, Leyden JJ et al. Management of Acne. A report from a global alliance to improve outcomes of acne. J Am Acad Dermatol. 2003;49:1-37.

Sagransky M, Yentzer BA, Feldman SR. Benzoyl peroxide: a review of its current use in the treatment of acne vulgaris. Expert Opin Pharmacother. 2009;10(15):2555-62.

Eichenfield LF, Alió Sáenz AB. Safety and efficacy of clindamycin phosphate 1.2%-benzoyl peroxide 3% fixed-dose combination gel for the treatment of acne vulgaris: a phase 3, multicenter, randomized, double-blind, active- and vehicle-controlled study. J Drugs Dermatol. 2011;10(12):1382-96.

Ross JI, Snelling AM, Caenegie E, Coates P, Cunliffe WJ, Bettoli V et al. Antibiotic resistant acne: lessons from Europe. Br J Dermatol. 2003;148:467-78.

Weiss J. Current options of topical treatment of acne vulgaris. Pediatr Dermatol. 2007;14:480-8.

Savage LJ, Layton AM. Treating Acne Vulgaris: Systemic, Local and Combination Therapy. Expert Rev Clin Pharmacol. 2010;13:563-80.

Degitz K, Ochsendorf F. Pharmacotherapy of acne. Pharmacother. 2008;9:955-71

Dutil M. Benzoyl peroxide: enhancing antibiotic efficacy in acne management. Skin Therapy Lett. 2010;15(10):5-7.

Webster GF, Jeyden JJ, McGinley KJ, McArthur WP. Suppression of polymorphonuclear leucocyte chemotactic factor production in Propionibacterium acnes by subminimal inhibitory concentrations of tetracycline, ampicillin, minocycline, and erythromycin. Antimicrob Agents Chemother.1992;21:770-2.

Kubba A, Bajaj AK, Thappa DM, Sharma R, Vedamurthy M, Dhar S. Acne in India: Guidelines for management - IAA consensus document: Topical antibacterials. Indian J Dermatol Venereol Leprol. 2009;75:1-62.

Michael H, Gold MD. A New, Once-daily, Optimized, Fixed Combination of clindamycin Phosphate 1.2% and Low-concentration Benzoyl Peroxide 2.5% Gel for the Treatment of Moderate-to-Severe Acne. J Clin Aesthetic Dermatol. 2009;2(5):44-8.

Choudhury S, Chatterjee S, Sarkar DK, Dutta R N. Efficacy and safety of topical nadifloxacin and benzoyl peroxide versus clindamycin and benzoyl peroxide in acne vulgaris: A randomized controlled trial. Indian J Pharmacol. 2011;43:628-31.

Bojar RA, Cunliffe WJ, Holland KT. The short-term treatment of acne vulgaris with benzoyl peroxide: effects on the surface and follicular cutaneous microflora. Br J Dermatol. 1995;132:204-8.

Lookingbill DP, Chalker DK, Lindholm JS. Treatment of acne with a combination clindamycin/benzoyl peroxide gel compared with clindamycin gel, benzoyl peroxide gel and vehicle gel: combined results of two double-blind investigations. J Am Acad Dermatol. 1997;37:590-5.

Tucker R, Walton S. The role of benzoyl peroxide in the management of acne vulgaris. Pharm J. 2007;279:48-53.

Kligman AM, Leyden JJ, Stewart R. New uses for benzoyl peroxide: a broad-spectrum antimicrobial agent. Int J Dermatol. 1997;16:413-7.

Thiboutot D, Zaenglein A, Weiss J. An aqueous gel fixed combination of clindamycin phosphate 1.2% and benzoyl peroxide 2.5% for the once-daily treatment of moderate-to-severe acne vulgaris: assessment of efficacy and safety in 2,813 patients. J Am Acad Dermatol. 2008;59:792-800.

Cunliffe WJ, Holland KT, Bojar R, Levy SF. A randomized, double-blind comparison of a clindamycin phosphate/ benzoyl peroxide gel formulation and a matching clindamycin gel with respect to microbiologic activity and clinical efficacy in the topical treatment of acne vulgaris. Clin Ther. 2002;24:1117-33.

Leyden JJ, Hickman JG, Jarratt MT. The efficacy and safety of a combination benzoyl peroxide/clindamycin topical gel compared with benzoyl peroxide alone and a benzoyl peroxide/erythromycin combination product. J Cutan Med Surg. 2001;5(1):37-42.


Refbacks

  • There are currently no refbacks.


ISSN: 1560-9014