Efficacy of combination of intralesional corticosteroid injection and cryotherapy versus intralesional corticosteroid injection alone in patients of keloid

Md Qamrul Ahsan, Md Akram Ullah Sikder, Lubna Khondker

Abstract


Objective To compare the efficacy of combination of intralesional corticosteroid injection and cryotherapy with intralesional corticosteroid injection alone in patients of keloid.

 

Methods A clinical trial was carried out in the department of Dermatology and Venereology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh for duration of January 2013 to August 2013. About 30 patients (group A) were treated with intralesional triamcinolone acetonide with cryotherapy and 30 patients (group B) were treated with intralesional triamcinolone acetonide.

 

Results Improvement rate was highest for the lesions on the chest, which was 18 (34.6%) and lowest for back 3 (5.8%). Out of all patients from group A, the mean size of the lesions were 8.17cm, 5.90 cm, 4.32 cm, and 3.57 cm at 1st visit, 2nd visit, 3rd visit and 4th visit, respectively. In group B, the mean size of the lesions was 7.50 cm, 4.92 cm, 3.00 cm, and 4.75 cm at 1st visit, 2nd visit, 3rd visit and 4th visit, respectively. Among the patients of group A and B, 27 (90%) and 25 (83.3%) cases improved, respectively.

 

Conclusion Each of the treatment was individually effective in the treatment of keloid but study with a larger group of patients for longer period may result in superior outcome in clinical practice through improved compliance.

 


Keywords


Efficacy of intralesional corticosteroid, cryotherapy, keloid

Full Text:

PDF

References


Barara M, Mendiratta V, Chander R. Cryotherapy in treatment of keloids: Evaluation of factors affecting treatment outcome. J Cutan Aesthet Surg. 2012;5:185-9.

Layton AM, Yip J, Cunliffe WJ. A comparison of intralesional triamcinolone and cryosurgery in the treatment of acne keloids. Br J Dermatol. 1994;130:498-501.

Sharma S, Bhanot A, Kaur A, Dewan SP. Role of liquid nitrogen alone compared with combination of liquid nitrogen and intralesional triamcinolone acetonide in the treatment of small keloids. J Cosmet Dermatol. 2007;6:258-61.

Prabhu A, Sreekar H, Powar R, Uppin VM. A randomized controlled trial comparing the efficacy of intralesional 5-fluorouracil versus triamcinolone acetonide in the treatment of keloids. J Sci Soc. 2012;39:19-25.

Mutalik S. Treatment of keloids and hypertrophic scars. Indian J Dermatol Venereol Leprol. 2005;71:3-8.

Shepherd JP, Dawber RP. The response of keloid scars to cryosurgery. Plast Reconstr Surg. 1982;70:677-81.

Zouboulis CC. Principles of cutaneous cryosurgery: An update. Dermatology. 1999;198:111-7.

Rusciani L, Rossi G, Bono R. Use of cryotherapy in the treatment of keloids. J Dermatol Surg Oncol. 1993;19:529-34.

Cruz NI, Korchin L. Inhibition of human keloid fibroblast growth by isotretinoin and triamcinolone acetonide in vitro. Ann Plast Surg. 1994;33:401-5.

Robles DT, Moore E, Draznin M, Berg D. Keloids: Pathophysiology and management. Dermatol Online J. 2007;13 (3):9.

Pollack SV. Treatment of keloids. In: Wheeland RG, Ed. Cutaneous Surgery. Philadelphia: WB Saunders; 1994. p. 688-98.

Manuskiatti W, Fitzpatrick RE. Treatment response of keloids and hypertrophic sternotomy scars. Arch Dermatol. 2002;138:1149-55.

Berman B, Flores F. Recurrence rates of excised keloids treated with post operative triamcenolone acetonide injections or interferon α 2b injections. J Am Acad Dermatol. 1997;37:755-7.

Malakar S, Malakar R. Intralesional cryosurgery: Consequences, cautions and precautions. Indian J Dermatol. 2000;45:100-1.

English RS, Shenefelt PD. Keloids and hypertrophic scars. Dermatol Surg. 1999;25:631-8.

Kill J. Keloids treated with topical injection of triamcinolone acetonide (Kenalog), Immediate and long-term results. Scand J Plast Reconstr Surg. 1977;11:169-72.

Bock O, Schmid-Ott G, Malewski P, Mrowietz U. Quality of life of patients with keloid and hypertrophic scarring. Arch Dermatol Res. 2006;297:433-8.

Kelly AP: Medical and surgical therapies for keloids. Dermatol Ther. 2004;17:212-8.

Yosipovitch G. A Comparative Study of Combination Intralesional Corticosteroid with Cryotherapy versus Intralesional Corticosteroid and Cryotherapy Alone in the Treatment of Keloids in Adolescents. J Dermatol Surg Oncol. 1999;5:54-6.

El-Tonsy MH, Anber TE, El-Domyati MM, El-Din WH. Evaluation of ND-YAG Laser Versus Combined Cryotherapy and Intralesional Corticosteroid Injection in Treatment of Keloids and Hypertrophic Scars. Semin Cutan Med Surg. 1999;18:159-71.


Refbacks

  • There are currently no refbacks.


ISSN: 1560-9014