The role of ceramide, menthol, and polidocanol on pruritus, skin barrier function, and disease severity of mild atopic dermatitis

Authors

  • Menul Ayu Umborowati Dermatology and Venereology Department Faculty of Medicine Universitas Airlangga
  • Dewi Nurasrifah Dermatology and Venereology Department Faculty of Medicine Universitas Airlangga
  • Diah Mira Indramaya Dermatology and Venereology Department Faculty of Medicine Universitas Airlangga
  • Sylvia Anggraeni Dermatology and Venereology Department Faculty of Medicine Universitas Airlangga
  • Damayanti Damayanti Dermatology and Venereology Department Faculty of Medicine Universitas Airlangga
  • Cita Rosita Sigit Prakoeswa Dermatology and Venereology Department Faculty of Medicine Universitas Airlangga

Keywords:

atopic dermatitis, moisturizer, pruritus, skin barrier, severity

Abstract

Background Atopic Dermatitis (AD) relates with skin barrier defect. Unbearable itch leads to intense scratching, causing skin damage, and perpetuates the disease. The aim of this study is to investigate efficacy of topical ceramide, menthol, and polidocanol to decrease itch and AD severity, also improve skin barrier function. Methods Total 30 subjects were included in this pre-experimental, before-after observational study. The subjects were children 8-18 years old with mild atopic dermatitis. We evaluated SCORAD index and daily patient-based Patient Eczema Scoring Time (PEST) for AD severity, transepidermal water loss (TEWL) using Tewameter to represent skin barrier function, and also visual analog scale (VAS) to observe itch. The preparation was applied twice daily for 4 weeks. The progression of AD after application, along with side effects, was evaluated on 5 minutes, week 1, 2, and 4. Results SCORAD index started to decrease after 1-week application. PEST and itch VAS decreased as immediate as 5 minutes after application. Skin barrier function also improved represented by declining of TEWL values. The differences were statistically significant (P < 0.05). Conclusion Combination of ceramide, menthol, and polidocanol suppress itchy and disease severity, also improve skin barrier function in AD patients. 

Author Biographies

Menul Ayu Umborowati, Dermatology and Venereology Department Faculty of Medicine Universitas Airlangga

Menul Ayu Umborowati, MD is an Indonesian board-certified dermato-venereologist. She completed medical doctor in Gadjah Mada University and trained as dermato-venereology residency at Universitas Airlangga, Indonesia. She is now lecturer and researcher in Dermatology and Venereology Department, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia. Her major field of interest is immunodermatology and cosmetic dermatology. Her publications and researches are about patogenesis and moisturiser for atopic dermatitis, cutaneous adverse drug reaction, management of melasma in outpatient clinic, dermatotherapy, and amniotic membrane stemcell metabolite product for photoaging.

Dewi Nurasrifah, Dermatology and Venereology Department Faculty of Medicine Universitas Airlangga

Dewi Nurasrifah, MD is board-certified dermatologist in Surabaya, Indonesia

Diah Mira Indramaya, Dermatology and Venereology Department Faculty of Medicine Universitas Airlangga

Diah Mira Indramaya, MD is an Indonesian board-certified dermato-venereologist. She is now lecturer and researcher in Dermatology and Venereology Department, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia. Her major field of interest is dermatopathology and cosmetic dermatology. She already published many articles on her fields in some Indonesian journals.

Sylvia Anggraeni, Dermatology and Venereology Department Faculty of Medicine Universitas Airlangga

Sylvia Anggraeni, MD is an Indonesian board-certified dermato-venereologist. She is now lecturer and researcher in Dermatology and Venereology Department, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia. Her major field of interest is immunodermatology and Dermatomicology. She already published many articles on her fields in some Indonesian journals.

Damayanti Damayanti, Dermatology and Venereology Department Faculty of Medicine Universitas Airlangga

Sylvia Anggraeni, MD is an Indonesian board-certified dermato-venereologist. She is now lecturer and researcher in Dermatology and Venereology Department, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia. Her major field of interest is immunodermatology and Dermato-geriatry. She already published many articles on her fields in some Indonesian journals.

Cita Rosita Sigit Prakoeswa, Dermatology and Venereology Department Faculty of Medicine Universitas Airlangga

Prof. Cita Rosita Sigit Prakoeswa, MD, PhD is dermato-venereology professor from Universitas Airlangga, Surabaya Indonesia. Her major field are Allergy-immunology and Leprosy. She has many researches and publications about Leprosy, atopic dermatitis, stem cell, probiotic, etc

References

M. Yulianto Listiawan, MD, PhD (President of Indonesian Society of Dermatology and Venereology)

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Published

2020-08-07

How to Cite

1.
Umborowati MA, Nurasrifah D, Indramaya DM, Anggraeni S, Damayanti D, Prakoeswa CRS. The role of ceramide, menthol, and polidocanol on pruritus, skin barrier function, and disease severity of mild atopic dermatitis. J Pak Assoc Dermatol [Internet]. 2020Aug.7 [cited 2025Mar.25];30(1):98-105. Available from: http://jpad.com.pk/index.php/jpad/article/view/1288

Issue

Vol. 30 No. 1 (2020): January - March

Section

Original Articles

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