A comparative study of efficacy & tolerability of 30% salicylic acid versus 20% salicylic acid + 10% mandelic acid peel for acne vulgaris

Mohamed Sidiq, Seethalakshmi Ganga vellaisamy, Kannan Gopalan, Muthusamy Kandasamy


Introduction Acne vulgaris mostly affects the face resulting in low self esteem, depression and  social phobia thereby affecting the quality of life. Chemical peeling is still considered a simple procedure, requiring hardly any instrumentation  which is done in day to day  practice to treat acne vulgaris.


Objective To compare the efficacy of 30 % salicylic acid peel (SA) versus 20% salicyclic acid peel with 10% mandelic acid peel (SMP) in the treatment of acne vulgaris.


Materials and Methods A total of 50 patients were selected and divided into two groups; A (treated with 30% salicylic acid peel) & B (treated with 20% salicyclic acid peel with 10% mandelic acid peel). Data were coded and analyzed.


Results Of the 50 participants, 41 completed all four sessions. Among those 41 patients, 23 belonged to group A and 18 belonged to group B. In group A, 51–75 % improvement was noted in 22 (96%) patients and one (4%) had 26-50% improvement. In group B, 51–75 % improvement was noted in 14 (78%) patients, Three (17%) had 26–50 % improvement, one (6%) patient showed less than 25% improvement.


Conclusion This study infers that reduction in active acne lesions was much more with 30% salicylic acid peel, whereas postacne melanosis reduced much with the combination peel (SMP). We conclude that both salicylic acid (SA) and Salicylic+Mandelic acid Peel are efficient, well tolerated and reasonably safe procedure that can be used as treatment modality in acne vulgaris.


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Acne vulgaris, mandelic acid peel, post acne melanosis, salicylic acid peel

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