Frequency of thyroid disorders in patients with chronic plaque psoriasis and psoriatic arthritis

Yousuf Abd Mallick


Objective  To calculate the frequency of thyroid disorders in patients with chronic plaque psoriasis and psoriatic arthritis.


Methods The cross-sectional study was conducted in Dermatology department, Sir Syed College of Medical Sciences and Sir Syed Hospital, Karachi. Study period was 6 months from 1st June 2017 to 30th November 2017. Clinically diagnosed or biopsy proven 112 cases of chronic plaque psoriasis with or without arthritis, of either gender, age 18 years and above were included via non-probability consecutive sampling technique.  Serum free T3, free T4 and TSH levels were performed and results were recorded.


Results In my study, the mean age was 43.51±13 years. Mean duration of disease was 7.75 years. Out of 112 patients, 53 (47.3%) were male and 59 (52.7%) were female. 52 (46.4%) patients had type I while 60 (53.6%) had type II plaque psoriasis. Psoriatic arthritis was present in 54 (48.2%) and absent in 58 (51.8%) patients. Mean BMI was 27±5.9 kg/m2 and 71 (63.4%) patients were obese. 17 (15.2%) patients were found to have thyroid disorders (P=<0.001); among these 13 patients had subclinical hypothyroidism. Thyroid function abnormalities were more commonly found in females (P=0.014). But no association of thyroid function abnormalities was noted with age of patients, type of plaque psoriasis, presence of psoriatic arthritis, duration of disease and BMI.


Conclusion This study suggests that thyroid disorders and subclinical hypothyroidism are frequent among psoriasis patients. Thyroid function abnormalities are statistically associated with female sex but not with age of patients, type of plaque psoriasis, presence of psoriatic arthritis, duration of disease and BMI.



Chronic plaque psoriasis, psoriatic arthritis, thyroid disorders, subclinical hypothyroidism, frequency

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