Efficacy and safety of intralesional 5-fluorouracil in treatment of warts

Tahir Kamal, Farhana Ahmad, Usma Iftikhar


Objective To determine the efficacy and safety to intralesional 5-flourouracil in the treatment of common warts.


Methods This  interventional study was conducted in the Department of Dermatology, PGMI/AMC/Lahore General Hospital Lahore from October, 2016 to July, 2017. 40 patients with warts were treated with intralesional 5-FU (0.1ml/cm2 of 5-FU, 50mg/ml), at the base of each wart. Injections were repeated every two weeks, maximum for six injections. Patients followed fortnightly upto 2 months after last injection for efficacy and safety.


Results Overall 30 (75%) patients (of all types of warts) showed excellent results (maximum six injections) and remained clear on follow-up after 2 months of last treatment session. Localized irritation and pain were the major side effects encountered in all patients.


Conclusion Intralesional 5-FU is an effective and safe treatment for treatment of common, plantar and genital warts.



Wart, 5-fluorouracil, intralesional

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