Frequency of Helicobacter pylori infection in patients of chronic spontaneous urticaria

Yousuf Abd Mallick, Sidra Akhlaq Hussain


Objective To calculate the frequency of Helicobacter pylori infection by stool antigen assays in patients of chronic spontaneous urticaria.


Methodology The study was cross-sectional & conducted in Dermatology outpatient department of Saifee Hospital Trust, Karachi, Pakistan. The duration of study was six months i.e. from July 1st 2017 to December 31st 2017. Clinically diagnosed, 130 adult cases of chronic spontaneous urticaria of either gender, age 18 years and above, having urticaria for 6 months or more were included via non-probability consecutive sampling technique. Stool for H pylori antigen assays were performed and results were recorded.


Results  In our study, the mean age was 33.4 ± 13.0 years. Mean duration of symptoms was 1.5 years. Out of 130 patients, 98 (75.4%) were female and 32 (24.6%) were male with a female to male ratio of 3:1. In our study, those who have urticaria for longer duration (more than 1 year) were more likely to have H pylori infection as compared to those who have shorter duration (P=<0.009). Overall, stool for H pylori antigen test was positive in 39 (30%) patients with urticaria (P=<0.001).


Conclusion The number of cases with positive stool for H pylori antigen among chronic spontaneous urticaria patients is significantly higher and it is one of the main aetiopathogenic factors for this disease. Cases of urticaria should be routinely screened for H pylori infection and eradication therapy will be useful for control of disease.



Chronic spontaneous urticaria, H pylori, stool for H pylori antigen, frequency

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