Comparison of efficacy and safety of topical betamethasone valerate 0.1% with narrowband-UVB in atopic dermatitis

Rajani Agrawal, Bushra Bashir, Sadia Qayuum, Sara Inayat, Khawar Khurshid, Sabrina Suhail Pal, Faria Altaf

Abstract


Objective To compare the efficacy and safety of topical betamethasone valerate 0.1% with narrowband ultraviolet B (NB-UVB) therapy in atopic dermatitis.

 

Method Sixty patients with AD fulfilling the inclusion criteria were entered in the study. Patients were divided into 2 groups. Group A were given betamethasone valerate 0.1% twice a day for 4 weeks. Group B were given NB-UVB thrice a week for 8 weeks. Starting dose was 75% of minimal erythema dose (MED) for the skin type III and IV. Dose was increased by 20% on each visit as tolerated by the patients. During treatment patients were assessed at 2nd and 4th week for betamethasone valerate and 2nd, 4th, 6th and 8th week for NB-UVB.

 

Results 84% patients in group A (betamethasone) showed >50% reduction in Scoring of Atopic Dermatitis (SCORAD) whereas 94% patients in group B (NB-UVB) showed >50% reduction in SCORAD (p=0.554).  Side effects were seen in 34% patients in group A and 20% in group B.

 

Conclusion Both betamethasone valerate 0.1% and NB-UVB are almost equal in terms of efficacy but NB-UVB is more safe than betamethasone valerate 0.1%.

 


Keywords


Atopic dermatitis, betamethasone Valerate 0.1%, efficacy, NB-UVB, safety

Full Text:

PDF

References


Friedmann PS, Holden CA. Atopic dermatitis. In: Burns T, Breathnach S, Cox N, Griffiths C, editors. Rook’s Textbook of Dermatology, 8th edn. London: Blackwell Science; 2010. P. 24.1-18.

Leung DY, Bieber T. Atopic dermatitis. Lancet. 2003;361:151-60.

Novak N, Bieber T, Leung DYM. Immune mechanisms leading to atopic dermatitis. J Allergy Clin Immunol. 2003;112:128-39.

Baldo A, Cafiero M, Di Caterino P, Di Costanzo L. Tacrolimus ointment in the management of atopic dermatitis. Clin Cosmet Invest Dermatol. 2009;2:1-7.

Schmitt J, Schakel K , Schmitt N. Systemic treatment of severe atopic dermatitis: A systematic review. Acta Derm Venereol. 2007;87:100-11.

Reynolds NJ, Franklin V, Gray JC , Diffey BL, Farr PM. Narrowband ultraviolet B and broadband ultraviolet A phototherapy in atopic dermatitis. Lancet. 2001;357:2012-6.

Jekler J, Larko O. UVB phototherapy of atopic dermatitis. Br J Dermatol. 1988;119:697-705.

Dogra S, Kanwar AJ. Narrowband UVB phototherapy in dermatology. Indian J Dermatol Venereol Leprol. 2004;70:205-9.

Ahmed I, Ansari M, Malick K. Childhood eczema: a comparative analysis. J Pak Assoc Dermatol. 2003;13:164-70.

Nasreen S, Wahid Z, Ahmed A. Atopic dermatitis: Frequency of associated disorder in children. J Pak Assoc Dermatol. 2005;15:125-9.

Kanwar AJ, De D. Epidemiology and clinical features of atopic dermatitis in India. Indian J Dermatol. 2011;56:471-5.

Johanna M, Anita R, Hannele V, Sakari R. One-year treatment with 0.1% tacrolimus ointment versus a corticosteroid regimen in adults with moderate to severe atopic dermatitis: A randomized, double-blind, comparative trial. Acta Derm Venereol. 2010;90:170-4.

Aschoff R, Schmitt J, Knuschke P, Koch E, Bräutigam M, Meurer M. Evaluation of the atrophogenic potential of hydrocortisone 1% cream and pimecrolimus 1% cream in involved forehead skin of patients with atopic dermatitis using optical coherence tomography. Exp Dermatol. 2011;20:832-36.

Selvaag E, Caspersen L, Bech-Thomsen N, Wulf HC. Optimized UVB treatment of atopic dermatitis using skin reflectance measurements. A controlled, left-right comparison trial. Acta Derm Venereol. 2005;85:144-6.

Nakagawa H. Comparison of the efficacy and safety of 0.1% tacrolimus ointment with topical corticosteroids in adult patients with atopic dermatitis: review of randomized, double- blind clinical studies conducted in Japan. Clin Drug Investig. 2006;26:235-46.

Der-Petrossian M, Seeber A, Honigsmann H, Tanew A. Half-side comparison study on the efficacy of 8-methoxypsoralen bath- PUVA versus narrow-band ultraviolet phototherapy in patients with severe atopic dermatitis. Br J Dermatol. 2000;142:39-43.

Grundmann-Kollmann M, Behrens S, Podda M, Peter RU, Kaufmann R, Kerscher M. Phototherapy for atopic eczema with narrow-band UVB. J Am Acad Dermatol. 1999;40:995-7.


Refbacks

  • There are currently no refbacks.


ISSN: 1560-9014