Comparison of efficacy and safety of topical betamethasone valerate 0.1% with narrowband-UVB in atopic dermatitis

Rajani Agrawal, Bushra Bashir, Sadia Qayuum, Sara Inayat, Khawar Khurshid, Sabrina Suhail Pal, Faria Altaf


Objective To compare the efficacy and safety of topical betamethasone valerate 0.1% with narrowband ultraviolet B (NB-UVB) therapy in atopic dermatitis.


Method Sixty patients with AD fulfilling the inclusion criteria were entered in the study. Patients were divided into 2 groups. Group A were given betamethasone valerate 0.1% twice a day for 4 weeks. Group B were given NB-UVB thrice a week for 8 weeks. Starting dose was 75% of minimal erythema dose (MED) for the skin type III and IV. Dose was increased by 20% on each visit as tolerated by the patients. During treatment patients were assessed at 2nd and 4th week for betamethasone valerate and 2nd, 4th, 6th and 8th week for NB-UVB.


Results 84% patients in group A (betamethasone) showed >50% reduction in Scoring of Atopic Dermatitis (SCORAD) whereas 94% patients in group B (NB-UVB) showed >50% reduction in SCORAD (p=0.554).  Side effects were seen in 34% patients in group A and 20% in group B.


Conclusion Both betamethasone valerate 0.1% and NB-UVB are almost equal in terms of efficacy but NB-UVB is more safe than betamethasone valerate 0.1%.



Atopic dermatitis, betamethasone Valerate 0.1%, efficacy, NB-UVB, safety

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