Association of dyslipidemia with psoriasis

Uzma Akbar Mirza, Ijaz Hussain, Usma Iftikhar

Abstract


Objective To determine association between psoriasis and dyslipidemia.

 

Methods This cross-sectional study was done at Dermatology Department, Lahore General Hospital, Lahore. Non-probability convenient sampling 106 cases and 106 age-and gender-matched controls) were included in this research. Blood samples from both cases and controls were taken after fasting of 12 hours. Informed consent was taken in order to determine the level of their lipid profile. SPSS 21 version was utilized to evaluate the collected data.

 

Results The mean age of cases and controls in current study was 31.74± 5.27 and 31.24 ±5.29 years, respectively. In cases there were 51 (48.1%) female and 55(51.9%) male patients while in control group, there were 68 (64.1%) males and 38 (35.9%) females. There was significant association of cases and dyslipidemia and there were 54 times more chances of having dyslipidemia for cases. The overall logistic model showed that there were 219.633 times more chances of dyslipidemia for cases, moreover, raised triglyceride and low HDL had significant association with cases while age and gender have no significant role.

 

Conclusion Dyslipidemia is positively associated with psoriasis regardless of age, gender and severity of disease. As dyslipidemia is a major risk factor for microvascular complications and proved risk factor for cardiovascular disease, we must include serum fasting lipid profile as a routine investigation in psoriatic patients and early screening must be ensured to minimize the risk of cardio vascular diseases.

 


Keywords


Psoriasis, dyslipidemia, cardiovascular disease, lipid profile

Full Text:

PDF

References


Cimmino MA. Epidemiology of psoriasis and psoriatic arthritis. Reumatismo. 2007;59 Supple 1:19-24.

Gelfand JM, Weinstein R, Porter SB, Neimann AL, Berlin JA, Margolis DJ. Prevalence and treatment of psoriasis in the United Kingdom: a population-based study. Arch Dermatol. 2005;141:1537-41.

Neimann AL, Porter SB, Gelfand JM. The epidemiology of psoriasis. Expert Rev Dermatol. 2006;1(1):63-75.

Traub M, Marshall K. Psoriasis--pathophysiology, conventional, and alternative approaches to treatment. Altern Med Rev. 2007;12(4):319-31.

Cohen AD, Sherf M, Vidavsky L, Vardy DA, Shapiro J, Meyerovitch J. Association between psoriasis and the metabolic syndrome. Dermatology. 2008;216:152-5.

Ma C, Harskamp CT, Armstrong EJ, Armstrong AW. The association between psoriasis and dyslipidaemia: a systematic review. Br J Dermatol. 2013;168:486-95.

Santos M, Fonseca HM, Jalkh AP, Gomes GP, Cavalcante AD. Obesity and dyslipidemia in patients with psoriasis treated at a dermatologic clinic in Manaus. An Bras Dermatol. 2013;88:913-6.

Augustin M, Reich K, Glaeske G, Schaefer I, Radtke M. Co-morbidity and age-related prevalence of psoriasis: analysis of health insurance data in Germany. Acta Dermato-Venereologica. 2010;90:147-51.

Pearson KC, Armstrong A. Psoriasis and cardiovascular disease: epidemiology, mechanisms, and clinical implications. Psoriasis Targets Ther. 2012;2:1-11.

Miller IM, Ellervik C, Yazdanyar S, Jemec GB. Meta-analysis of psoriasis, cardiovascular disease, and associated risk factors. J Am Acad Dermatol. 2013;69:1014-24.

Fodor G. Primary prevention of CVD: treating dyslipidaemia. BMJ Clin Evid. 2010;2010.

Bhor U, Pande S. Scoring systems in dermatology. Indian J Dermatol Venereol Leprol. 2006;72:315.

Gottlieb AB, Dann F. Comorbidities in patients with psoriasis. Am J Med. 2009;122:1150.e1-9.

Salihbegovic EM, Hadzigrahic N, Suljagic E, Kurtalic N, Hadzic J, Zejcirovic A et al. Psoriasis and dyslipidemia. Mater Sociomedica. 2015;27(1):15.

Ma C, Schupp CW, Armstrong EJ, Armstrong AW. Psoriasis and dyslipidemia: a population‐based study analyzing the National Health and Nutrition Examination Survey (NHANES). J Eur Acad Dermatol Venereol. 2014;28:1109-12.

Dsouza PH, Kuruville M. Dyslipidemia in psoriasis: as a risk for cardiovascular disease. Msjonline.org

Nisa N, Qazi MA. Prevalence of metabolic syndrome in patients with psoriasis. Indian J Dermatol Venereol Leprol. 2010;76(6):662.

Gupta M, Chari S, Borkar M, Ch M. Dyslipidemia and oxidative stress in patients of psoriasis. Biomed Res. 2011;22(2).


Refbacks

  • There are currently no refbacks.


ISSN: 1560-9014