Chronic urticaria and dyspepsia: Association and treatment, an experimental study

Hamad Ayed Alfahaad


Objective To determine the prevalence of Helicobacte pylori infection among chronic idiopathic urticaria patients and to assess their urticarial response after the eradication of H. pylori.


Methods This study was a non-controlled, interventional study that was carried during the period from January 2016 to November 2016 at Dermatology Clinic, King Khalid Hospital, Najran, KSA. A total of 104 patients were included in our study. The patients who were positive for H. pylori were started on the eradication therapy. The effectiveness of the eradication therapy was assessed by repeating the H. pylori Urea Breath Test (UBT) after 4 weeks. Urticarial response was assessed 12 weeks after the eradication.


Results The prevalence of chronic idiopathic urticaria (CIU) at our dermatology clinic was 0.6%. The patients were predominantly females (76.4%), and the highest number (69.4%) belonged to the age group ’20-50 years’. Of the study subjects (62.5%) had positive H. pylori, (91%) achieved eradication of H. Pylori while (9%) not. Of the cases (75.6%) showed significant improvement in their urticarial symptoms after eradication of H. pylori, while (24.4%) showed no significant improvement of their urticarial symptoms.


Conclusion H. pylori should be specifically investigated for all chronic urticaria patients and the eradication therapy advised for those who have are positive for H. pylori.



Chronic urticaria, Helicobacter pylori

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