Efficacy and safety of blue light versus 4% topical benzoyl peroxide in mild to moderate acne

Ashba Nasir Cheema, Uzma Ameen, Rabia Javaid, Muhammad Azam Bokhari


Objective To determine the efficacy and safety of blue light in comparison with 4% topical benzoyl peroxide (BPO) in mild to moderate acne.


Methods This randomized controlled trial, carried out in the Department of Dermatology at Services Institute of Medical Sciences/Services Hospital, Lahore, included 124 patients age ranging from 14-35 years having mild to moderate acne. Patients were randomized to receive blue light therapy (group I) or topical 4% BPO twice daily (group II). Efficacy was determined at week 8 by comparing % reduction in number of lesions. Side effects were noted during treatment period.


Results Total 124 patients were randomly divided into two groups. Group I, 62 (50%) patients were treated with blue light therapy and group B, 62 (50%) patients were treated with 4% topical BPO. 52 patients were male (41.9%) whereas 72 were females (58.1%). The mean age of the patient was 23.02 ± 6.3 years. The efficacy of the treatment in term of % reduction in the number of lesions was more in blue light group as compared to 4% topical BPO group, (76% vs. 60%), P <0.05. Blue light group was safer as compared to 4% topical BPO group (100% vs. 91%). 


Conclusion Blue light is more effective and safe therapy for mild to moderate acne patients as compared to 4% topical benzoyl peroxide.



Benzoyl peroxide, acnes, blue light

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Cunliffe WJ, Goulden V. Phototherapy and acne vulgaris. Br J Dermatol. 2000;142:855-6.

Thomas S. Topical antibiotics and benzoyl peroxide for treatment of acne. Am Fam Physician, 2003 [online]. Available at: http://www.aafp.org/afp/2012/1015/p 734.html, July 1; 88(1).

Hasibur MR, Meraj Z. Combination of low-dose isotretinoin and pulsed oral azithromycin for maximizing efficacy of acne treatment. Mymensingh Med J. 2013;22(1):42-8.

Salvaggio HL, Zaenglein AL Examining the use of oral contraceptives in the management of acne. Int J Womens Health. 2010;2:69-76.

Pierard-Franchimont C, Goffin V, Decroix J, Pierard GE. A multicenter randomized trial of ketoconazole 2% and zinc pyrithione 1% shampoos in severe dandruff and seborrheic dermatitis. Skin Pharmacol Appl Skin Physiol. 2014;15:434-41.

Kleinpenning MM, Smits T, Frunt HM, Van Erp PE, Vande Kerkhof PC, Gerritson RM. Clinical and histological effects of blue light on normal skin. Photodermatol Photoimmunol Photomed. 2010;26:16-21.

Grove G, Zerweck C, Gwazdauskas J. Tolerability and irritation potential of four topical acne regimens in healthy subjects. J Drugs Dermatol. 2013;12:644-9.

Wheeland RG, Koreck A. Safety and effectiveness of a new blue light device for the self treatment of mild to moderate acnes. J Clin Aesthet Dermatol. 2012;5:25-31.

Collier CN, Harper JC, Cantrell WC, Wang W, Foster KW et al. The prevalence of acne in adults 20 years and older. J Am Acad Dermatol. 2008;58:56-9.

de Arruda LHF, Kodani V, Filho AB, Mazzaro CB. A Prospective randomized, open and comparative study to evaluate the safety and efficacy of blue light treatment versus a topical benzoyl peroxide 5% formulation in patients with acne grade II and III. An Bras Dermatol. 2009;84:463-8.

Shalita AR, Cunningham WJ, Leyden JJ, Pochi PE, Strauss JS. Isotretinoin treatment of acne and related disorders: an update. J Am Acad Dermatol. 1983;9:629-38.

Ammad S, Gonzales M, Edwards C, Finlay AY, Mills C. An assessment of the efficacy of blue light phototherapy in the treatment of acne vulgaris. J Cosmet Dermatol. 2008;7:180-8.

Omi T, Bjerring P, Sato S, Kawana S, Hankins RW, Honda M. 420 nm intense continuous light therapy for acne. J Cosmet Laser Ther. 2004;6:156-61.

Gold MH, Sensing W, Biron JA. Clinical efficacy of home-use blue-light therapy for mild-to moderate acne. J Cosmet Laser Ther. 2011;13:308-14.

Babaeinejad SH, Fouladi RF. The efficacy, safety and tolerability of adapalene versus benzoyl peroxide in the treatment of mild acne vulgaris: a randomized trial. J Drugs Dermatol. 2013;12:1033-8.

Kawashima M, Hashimoto H, Alio Sáenz AB, Ono M, Yamada M. Is benzoyl peroxide 3% topical gel effective and safe in the treatment of acne vulgaris in Japanese patients? A multicenter, randomized, double-blind, vehicle-controlled, parallel-group study. J Dermatol. 2014;41:795-801.


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