Association of plasma D-dimer concentration with systemic sclerosis

MA Hussain, MR Rahim, Muhammad Noor Alam, MR Haque

Abstract


Objectives To establish the relationship between the level of plasma D-dimer concentration and systemic sclerosis.

 

Methods This cross-sectional study was conducted in the department of dermatology and venereology, Ibn Sina Medical College & Hospital, Dhaka for one year. This study included 56 patients of systemic sclerosis. Systemic sclerosis was diagnosed by the panel of expert on the basis of history and American College of Rheumatology criteria. Statistical analysis of the results was obtained by using Windows based computer software devised with statistical package for social sciences (SPSS-20) (SPSS inc Chicago IL,USA).

 

Results The mean age of patients was 44.00 years. Majority were female (73.2%).  Majority (76.8%) had diffuse cutaneous systemic sclerosis type. Higher level of plasma D-dimer was found in diffuse cutaneous systemic sclerosis than limited cutaneous systemic sclerosis, 538  mg/dl vs. 362 mg/dl (P<0.05).

 

Conclusion This study demonstrated that systemic sclerosis (SSc) patients with diffuse subset are characterized by increased plasma D-dimer values, reflecting a potential activation of both the hemostatic and fibrinolytic cascades, which might finally predispose these patients to thrombotic complications.

 


Keywords


Systemic sclerosis, diffuse cutaneous type, localized cutaneous type, D-dimers

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References


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