Association of plasma D-dimer concentration with systemic sclerosis

MA Hussain, MR Rahim, Muhammad Noor Alam, MR Haque


Objectives To establish the relationship between the level of plasma D-dimer concentration and systemic sclerosis.


Methods This cross-sectional study was conducted in the department of dermatology and venereology, Ibn Sina Medical College & Hospital, Dhaka for one year. This study included 56 patients of systemic sclerosis. Systemic sclerosis was diagnosed by the panel of expert on the basis of history and American College of Rheumatology criteria. Statistical analysis of the results was obtained by using Windows based computer software devised with statistical package for social sciences (SPSS-20) (SPSS inc Chicago IL,USA).


Results The mean age of patients was 44.00 years. Majority were female (73.2%).  Majority (76.8%) had diffuse cutaneous systemic sclerosis type. Higher level of plasma D-dimer was found in diffuse cutaneous systemic sclerosis than limited cutaneous systemic sclerosis, 538  mg/dl vs. 362 mg/dl (P<0.05).


Conclusion This study demonstrated that systemic sclerosis (SSc) patients with diffuse subset are characterized by increased plasma D-dimer values, reflecting a potential activation of both the hemostatic and fibrinolytic cascades, which might finally predispose these patients to thrombotic complications.



Systemic sclerosis, diffuse cutaneous type, localized cutaneous type, D-dimers

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Moinzadeh P, Denton Christopher P, Krieg T, Black Carol M. Scleroderma. Fitzpatrick’s Dermatology in General Medicine, 8th edn. Philadelphia: McGraw-Hill; 2012. P. 120-140.

Viswanath V, Meghana M Phiske MM, Vinay V Gopalani VV. Systemic Sclerosis: Current Concepts in Pathogenesis and Therapeutic Aspects of Dermatological Manifestations. Indian J Dermatol. 2013;58:255-68.

Ho M, Veale D, Eastmond C, Nuki G, Belch J. Macrovascular disease and systemic sclerosis. Ann Rheum Dis. 2000;59;39-43.

Prisco D, Antonucci E, Marcucci R. D-dimer in the year 2000, Current data and new perspectives. Ann Ital Med Int. 2000;l15:267-72.

Falanga V, Kruskal JB, Franks JJ. Fibrin and fibrinogen-related antigens in systemic sclerosis (scleroderma). J Am Acad Dermatol. 1991;25:771-5.

Lippi G, Volpe A, Caramaschi P, Salvagno GL, Montagnana M, Guidi GC. Plasma D-dimer concentration in patients with systemic sclerosis. Thromb J. 2006;4:2.

Maeda M, Kachi H, Mori S. Plasma levels of molecular markers of blood coagulation and fibrinolysis in progressive systemic sclerosis (PSS). J Dermatol Sci. 1996;11:223-7.

Komarov A, Panchenko EP, Dobrovolsky AB, Karpov Y, Deev A, Titaeva E et al. D-dimer and platelet aggregability are related to thrombotic events in patients with peripheral arterial occlusive disease. Eur Heart J. 2002;23:1309-16.

Lowe GDO. Can haematological tests predict cardiovascular risk? The 2005 Kettle Lecture. Br J Haematol. 2006;133:232-50.

Morange PE, Bickel C, Nicaud V, Schnabel R, Rupprecht HJ, Peetz D et al. Haemostatic factors and the risk of cardiovascular death in patients with coronary disease: the AtheroGene study. Arterioscler Thromb Vasc Biol. 2006;26:2793-9.

Nylaende M, Kroese A, Stranden E, Morken B, Sandbaek G, Lindahl AK et al. Prothrombotic activity is associated with the anatomical as well as the functional severity of peripheral arterial occlusive disease. Thromb Haemost. 2006;95:702-7.

Rudnicka AR, Rumley A, Lowe GD, Strachan DP. Diurnal, seasonal, and blood-processing patterns in levels of circulating fibrinogen, fibrin D-dimer, C-reactive protein, tissue plasminogen activator, and von Willebrand factor in a 45-year-old population. Circulation. 2007;115:996-1003.

Tzoulaki I, Murray GD, Price JF, Smith FB, Lee AJ, Rumley A et al. Hemostatic factors, inflammatory markers, and progressive peripheral atherosclerosis. The Edinburgh Artery Study. Am J Epidemiol. 2006;163:334-41.

Valentini G, Della Rossa A, Bombardieri S, Bencivelli W, Silman AJ, D'Angelo S et al. European multicentre study to define disease activity criteria for systemic sclerosis. II. Identification of disease activity variables and development of preliminary activity indexes. Ann Rheum Dis. 2001;60:592-8.

Medsger TA Jr, Bombardieri S, Czirjak L, Scorza R, Della Rossa A, Bencivelli W. Assessment of disease severity and prognosis. Clin Exp Rheumatol. 2003;21:S42-6.


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