Clinico-pathological profile of Systemic Sclerosis in a tertiary care center

Dilip Kumar SA, Alaka Sahu

Abstract


Objective To find out the profile of cutaneous and systemic features of systemic sclerosis (SSc) in people of East-Central part of India.

 

Methods This was a cross-sectional descriptive study conducted over eight years in a tertiary care center. All the patients of SSc were evaluated for cutaneous and systemic involvement.

 

Results 54 cases (48 females and 6 males) of SSc were evaluated. Mean age was 31.81±14.52 years. We found microstomia in 88.8%, sclerodactyly 88.8%, Raynaud’s phenomenon in 81.4%,  salt-and-pepper pigmentation in 70.3%, fingertip ulceration in 66.6%, pinched nose in 61.1%, radial furrows around mouth in 33.3%, diffuse alopecia in 18.5%, nail changes in 18.5%, calcinosis cutis in 7.4% and digital gangrene in 5.6% cases. Among the systemic features, we observed arthralgia in 55.5%, dyspnea on exertion in 55.5%, dysphagia in 51.8%, esophageal reflux in 46.2%, cough in 11.1%, and palpitation in 7.4% cases. Antinuclear antibody (ANA) was positive in 85.1%, abnormal pulmonary function test in 59.2%, abnormal X-ray hand in 33.3% and proteinuria in 7.4% cases.

 

Conclusion Pulmonary, renal and cardiac involvement were less in our study population as compared to other studies.

 


Keywords


Systemic sclerosis, cutaneous features, systemic features

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References


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