Hyperuricemia in female and male patients of chronic plaque psoriasis

Hafiz Bashir Ahmed, Farhan Mir, Muhammad Suleman Pirzado, Ajmal Rashid

Abstract


Objective To determine hyperuricemia in patients with chronic plaque psoriasis.

 

Methods Out of 194, 97 biopsy proven patients of psoriasis were taken as cases and 97 participants coming to OPD with any other skin disease like acne, alopecia, dermatomycosis etc. as controls. 5ml of venous blood was drawn in sterile syringe and using gel sample tube was sent to the laboratory for serum uric acid level.

 

Results There were 54.6% (106/194) male and 45.4% (88/194) female. Patients of psoriasis had hyperuricemia more frequently than controls (25.8% vs. 7.2%). Although male patients and similar frequency of hyperuricemia as in controls (15.2% vs. 6.7%), female patients had significantly more frequent than controls (35.3% vs. 8.1%).

 

Conclusion Hyperuricemia is a common finding in psoriatic patients. Its treatment might be clinically useful for the global treatment of patients. We found a female preponderance which could also be due to the overall more proportion of female patients visiting the clinic.

 


Keywords


Serum uric acid, chronic plaque psoriasis

Full Text:

PDF

References


Burden AD, Kirby B. Psoriasis and related disorders. Griffiths CEM, Barker J, Bleiker T, Chalmers R, Creamer D, editors. Rook's Textbook of Dermatology, 9th edition. Oxford: John Wiley & Sons; 2016. P. 35.1-35.48.

Ejaz A, Suhail M, Iftikhar A. Psoriasis in Pakistani population: Associations, comorbidities, and hematological profile. J Pak Assoc Dermatol. 2013;23:42-6.

Späh F. Inflammation in atherosclerosis and psoriasis: common pathogenic mechanisms and the potential for an integrated treatment approach. Br J Dermatol. 2008;159:10-7.

Ghazizadeh R, et al. Pathogenic mechanisms shared between psoriasis and cardiovascular disease. Int J Med Sci. 2010;7:284-9.

Reich K. The concept of psoriasis as a systemic inflammation: implications for disease management. J Eur Acad Dermatol Venereol. 2012;26:3-11.

Gisondi P, Dalle Vedove C, Girolomoni G. Efficacy and safety of secukinumab in chronic plaque psoriasis and psoriatic arthritis therapy. Dermatol Ther. 2014;4:1-9.

Ibrahim SE, Helmi A, Yousef TM, Hassan MS, Farouk N. Association of asymptomatic hyperuricemia and endothelial dysfunction in psoriatic arthritis. Egyptian Rheumatol. 2012;34:83-9.

Kwon H, et al. Cross‐sectional study on the correlation of serum uric acid with disease severity in Korean patients with psoriasis. Clin Exp Dermatol. 2011;36:473-8.

Lambert JR, Wright V. Serum uric acid levels in psoriatic arthritis. Ann Rheum Dis. 1977;36:264-7.

Feig DI, Kang D-H, Johnson RJ. Uric acid and cardiovascular risk. N Engl J Med. 2008;359:1811-21.

Jain V, Lal H. C-reactive protein and uric acid levels in patients with psoriasis. Indian J Clin Biochem. 2011;26:309-11.

Tickner A, Mier P. Serum cholesterol, uric acid and proteins in psoriasis. Br J Dermatol. 1960;72:131-7.

Lea WA, Curtis AC, Bernstein I. Serum uric acid levels in psoriasis. J Invest Dermatol. 1958;31:269-71.

Ishizaka N, Ishizaka Y, Toda E, Nagai R, Yamakado M. Association between serum uric acid, metabolic syndrome, and carotid atherosclerosis in Japanese individuals. Arterioscler Thromb Vasc Biol. 2005;25:1038-44.

Murray M, Bergstresser PR, Adams-Huet B, Cohen JB. Relationship of psoriasis severity to obesity using same‐gender siblings as controls for obesity. Clin Exp Dermatol. 2009;34:140-44.


Refbacks

  • There are currently no refbacks.


ISSN: 1560-9014