Efficacy of Autologus serum therapy in patients with chronic autoimmune urticaria: A prospective, open label study conducted in a tertiary care centre, India

Chintaginjala Aruna, Senthil Kumar A.L, Ramamurthy D.V.S.B, Sridevi K, Swapna Kameti, Naga Swetha T

Abstract


Objective To evaluate the efficacy of repeated autologous serum injections in patients with chronic autoimmune urticaria.

 

Methods Patients of chronic autoimmune urticaria were prospectively analyzed for the efficacy of eight consecutive weekly autologous serum injections with a post-intervention follow-up of 12 weeks. Total urticaria severity score (TSS) was calculated at the baseline, at the end of treatment and lastly at the end of 12 weeks of follow-up. Response to therapy was judged by the percentage reduction in baseline TSS at the end of treatment and again at the end of 12 weeks of follow-up.

 

Results Out of the 65 patients enrolled, 4 opted out of study after one or the first few doses. Among the rest of the 61 patients, 16.4% patients showed excellent response and 55.7% showed good to fair response to autologous serum therapy. Poor response was seen in 27.9% of the study population. Among the responders, only 15.9% [out of 72] relapsed at the end of 12 weeks of follow-up and at the end of study protocol we had 60.7% of the study population who could be labeled as completely or partially remitted with the treatment regimen.

 

Conclusion Autologous serum therapy is an effective therapy in patients with chronic autoimmune urticaria. Better response is seen in female patients with short duration of disease.

 


Keywords


Autologous serum therapy, Autologus serum skin test, Chronic autoimmune urticaria

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References


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ISSN: 1560-9014